{"product_id":"metal-catalyzed-n-h-and-o-h-insertion-yuling-hu-9783832548643","title":"Metal-Catalyzed N-H and O-H Insertion from Alpha-Diazocarbonyl Compounds","description":"Transition-metal catalyzed X-H insertions from alpha-diazocarbonyl compounds represent one of the most efficient approaches to form C--X bonds. The presented thesis is based on the synthesis and application of alpha-diazocarbonyl compounds in metal-catalyzed N-H insertion and the chemoenzymatic synthesis of heterocycles via a [Cu]\/[Rh] catalyzed intramolecular O-H insertion. In the first part, a straightforward approach via the Wittig reaction, gamma-Umpolung addition and diazo transfer reaction allowed the synthesis of unsaturated alpha-diazocarbonyl compounds with ease. In the second part, the newly synthesized (R textsubscript{p)-pseudo-ortho [2.2]paracyclophane-based bisoxazoline ligands presented superior reactivity. The obtained delta-amino alpha, beta-unsaturated carboxylic esters were used to synthesize hexahydroindoles, which are key intermediates in the synthesis route of Rostratin B-D. Additional investigation of alpha-diazocarbonyl compounds led to the enzymatic synthesis of O-Heterocycles. With the employment of enantiopure starting material obtained from ketoreductase LbADH, the enantioselectivity of each diastereomer from the O-H insertion product have been effectivity improved.\u003cbr\u003e\u003cbr\u003e\u003cb\u003eAuthor:\u003c\/b\u003e Yuling Hu\u003cbr\u003e\u003cb\u003eISBN-10:\u003c\/b\u003e 3832548645\u003cbr\u003e\u003cb\u003eISBN-13:\u003c\/b\u003e 9783832548643\u003cbr\u003e\u003cb\u003ePublisher:\u003c\/b\u003e Logos Verlag Berlin\u003cbr\u003e\u003cb\u003eLanguage:\u003c\/b\u003e English\u003cbr\u003e\u003cb\u003ePublished:\u003c\/b\u003e 03\/15\/2019\u003cbr\u003e\u003cb\u003ePages:\u003c\/b\u003e 208\u003cbr\u003e\u003cb\u003eFormat:\u003c\/b\u003e Paperback","brand":"Yuling Hu","offers":[{"title":"Paperback","offer_id":48450139422975,"sku":"9783832548643","price":71.0,"currency_code":"USD","in_stock":false}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0662\/2982\/9887\/files\/img_cbd3bfe0-bf28-4918-87b4-53998eb1e839.jpg?v=1777266381","url":"https:\/\/www.whiterainbookhouse.com\/products\/metal-catalyzed-n-h-and-o-h-insertion-yuling-hu-9783832548643","provider":"WR Book House","version":"1.0","type":"link"}