{"product_id":"metalloprotein-active-site-assembly-michael-k-johnson-9781119159834","title":"Metalloprotein Active Site Assembly","description":"\u003cp\u003e\u003cb\u003eSummarizes the essential biosynthetic pathways for assembly of metal cofactor sites in functional metalloproteins\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e\u003ci\u003eMetalloprotein Active Site Assembly\u003c\/i\u003e focuses on the processes that have evolved to orchestrate the assembly of metal cofactor sites in functional metalloproteins. It goes beyond the simple incorporation of single metal ions in a protein framework, and includes metal cluster assembly, metal-cofactor biosynthesis and insertion, and metal-based post-translational modifications of the protein environments that are necessary for function. Several examples of each of these areas have now been identified and studied; the current volume provides the current state-of-the-art understanding of the processes involved.\u003c\/p\u003e \u003cp\u003eAn excellent companion to the earlier book in this series\u003ci\u003e Metals in Cells\u003c\/i\u003e--which discussed both the positive and negative effects of cellular interactions with metals--this comprehensive book provides a diverse sampling of what is known about metalloprotein active site assembly processes. It covers all major biological transition metal components (Mn, Fe, Co, Ni, Mo), as well as the other inorganic components, metal-binding organic cofactors (e.g., heme, siroheme, cobalamin, molybdopterin), and post-translationally modified metal binding sites that make up the patchwork of evolved biological catalytic sites. The book compares and contrasts the biosynthetic assembly of active sites involving all biological metals. This has never been done before since it is a relatively new, fast-developing area of research.\u003c\/p\u003e \u003cp\u003e\u003ci\u003eMetalloprotein Active Site Assembly\u003c\/i\u003e is an ideal text for practitioners of inorganic biochemistry who are studying the biosynthetic pathways and gene clusters involved in active site assembly, and for inorganic chemists who want to apply the concepts learned to potential synthetic pathways to active site mimics.\u003c\/p\u003e\u003cbr\u003e\u003cbr\u003e\u003cb\u003eAuthor:\u003c\/b\u003e Michael K. Johnson\u003cbr\u003e\u003cb\u003eISBN-10:\u003c\/b\u003e 1119159830\u003cbr\u003e\u003cb\u003eISBN-13:\u003c\/b\u003e 9781119159834\u003cbr\u003e\u003cb\u003ePublisher:\u003c\/b\u003e Wiley\u003cbr\u003e\u003cb\u003eLanguage:\u003c\/b\u003e English\u003cbr\u003e\u003cb\u003ePublished:\u003c\/b\u003e 10\/02\/2017\u003cbr\u003e\u003cb\u003ePages:\u003c\/b\u003e 424\u003cbr\u003e\u003cb\u003eFormat:\u003c\/b\u003e Hardcover\u003cbr\u003e\u003cb\u003eWeight:\u003c\/b\u003e 3.09lbs\u003cbr\u003e\u003cb\u003eSize:\u003c\/b\u003e 11.20h x 8.70w x 0.90d","brand":"Michael K. Johnson","offers":[{"title":"Hardcover","offer_id":48807881900287,"sku":"9781119159834","price":206.95,"currency_code":"USD","in_stock":false}],"url":"https:\/\/www.whiterainbookhouse.com\/products\/metalloprotein-active-site-assembly-michael-k-johnson-9781119159834","provider":"WR Book House","version":"1.0","type":"link"}