{"product_id":"mineralizing-vesicles-massimo-bottini-9780323991582","title":"Mineralizing Vesicles: From Biochemical and Biophysical Properties to Their Roles in Physiology and Disease","description":"\u003cp\u003e\u003ci\u003eMineralizing Vesicles: From Biochemical and Biophysical Properties to Their Roles in Physiology and Disease\u003c\/i\u003e presents the state-of-the art in the properties of mineralizing EVs and their potential clinical applications. \u003c\/p\u003e \u003cp\u003eThe first chapter presents foundational biochemical and biological aspects of EVs. Next, the title coves the role of EVs in bone ossification and in cardiovascular and cartilage-related diseases. Considering the unique ability of this class of EVs to form apatite minerals assigned to their special biochemical machinery, three chapters of the book then focus on the enzymes catalysing the inorganic phosphate and calcium turn-over and the dynamic properties of the vesicles' peripheral proteins. Chapters describe the role of inorganic phosphate and calcium ions and of autophagy on the biogenesis and function of mineralizing EVs. Recent studies show that the lumen of mineralizing EVs is partially filled with miRNA, and a chapter therefore considers research on the possible function of these vesicles as signalosomes. The final five chapters of the book describe practical aspects of working with mineralizing EVs, including their purification, proteomic and biophysical analyses, the use of biomimetic models and mineralizing EVs in regenerative medicine. \u003c\/p\u003e \u003cp\u003eThis title presents, for the first time, a comprehensive account of mineralizing EVs and their potential clinical applications. It will be invaluable to researchers in the field. \u003c\/p\u003e\u003cbr\u003e\u003cbr\u003e\u003cb\u003eAuthor:\u003c\/b\u003e Massimo Bottini\u003cbr\u003e\u003cb\u003eISBN-10:\u003c\/b\u003e 0323991580\u003cbr\u003e\u003cb\u003eISBN-13:\u003c\/b\u003e 9780323991582\u003cbr\u003e\u003cb\u003ePublisher:\u003c\/b\u003e Academic Press\u003cbr\u003e\u003cb\u003eLanguage:\u003c\/b\u003e English\u003cbr\u003e\u003cb\u003ePublished:\u003c\/b\u003e 11\/21\/2023\u003cbr\u003e\u003cb\u003ePages:\u003c\/b\u003e 448\u003cbr\u003e\u003cb\u003eFormat:\u003c\/b\u003e Paperback","brand":"Massimo Bottini","offers":[{"title":"Paperback","offer_id":44069381636351,"sku":"9780323991582","price":175.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0662\/2982\/9887\/files\/img_fa491fb4-82a0-4a17-a069-302369bec07d.jpg?v=1685424407","url":"https:\/\/www.whiterainbookhouse.com\/products\/mineralizing-vesicles-massimo-bottini-9780323991582","provider":"WR Book House","version":"1.0","type":"link"}