{"product_id":"molecular-and-cellular-biology-of-igor-ed-roninson-9780306435478","title":"Molecular and Cellular Biology of Multidrug Resistance in Tumor Cells","description":"1 Characteristics of Multidrug Resistance in Human Tumor Cells.- 2 Development of Multidrug Resistance in Rodent Cell Lines.- 3 Cloning and Characterization of Mouse mdr Genes.- 4 Isolation and Characterization of the Human MDR (P-Glycoprotein) Genes.- 5 Amplification of Several Different Genes in Multidrug-Resistant Chinese Hamster Cell Lines.- 6 Molecular and Cytogenetic Analysis of Multidrug Resistance-Associated Gene Amplification in Chinese Hamster, Mouse Sarcoma, and Human Neuroblastoma Cells.- 7 Karyotype and Amplicon Evolution during Stepwise Development of Multidrug Resistance in Djungarian Hamster Cell Lines.- 8 Chromosome Localization of P-Glycoprotein Genes in Drug-Sensitive and -Resistant Human Cells.- 9 Structure and Evolution of P-Glycoproteins.- 10 Drug Accumulation and Binding in P-Glycoprotein-Associated Multidrug Resistance.- 11 Binding of Drugs and ATP by P-Glycoprotein and Transport of Drugs by Vesicles from Human Multidrug-Resistant Cells.- 12 Protein Changes in Multidrug-Resistant Cells.- 13 Membrane Lipids of Multidrug-Resistant Cells: Chemical Composition and Physical State.- 14 Expression of the MDR1 Gene in Normal Human Tissues.- 15 Expression of the Multidrug Resistant Gene in Human Cancer.- 16 Immunohistochemical Analysis of P-Glycoprotein Expression in Normal and Tumor Tissues in Humans.- 17 Quantitative Estimation of MDR1 mRNA Levels by Polymerase Chain Reaction.- 18 Collateral Sensitivity of Multidrug-Resistant Cells.- 19 Reversal of Multidrug Resistance by Calcium Channel Blockers and Other Agents.- 20 Growth Inhibition of Multidrug-Resistant Cells by Monoclonal Antibodies against P-Glycoprotein.- 21 P-Glycoprotein-Mediated Drug Resistance: Puzzles and Perspectives.\u003cbr\u003e\u003cbr\u003e\u003cb\u003eAuthor:\u003c\/b\u003e Igor Ed. Roninson\u003cbr\u003e\u003cb\u003eISBN-10:\u003c\/b\u003e 0306435470\u003cbr\u003e\u003cb\u003eISBN-13:\u003c\/b\u003e 9780306435478\u003cbr\u003e\u003cb\u003ePublisher:\u003c\/b\u003e Plenum Publishing Corporation\u003cbr\u003e\u003cb\u003eLanguage:\u003c\/b\u003e English\u003cbr\u003e\u003cb\u003ePublished:\u003c\/b\u003e 04\/30\/1991\u003cbr\u003e\u003cb\u003ePages:\u003c\/b\u003e 428\u003cbr\u003e\u003cb\u003eFormat:\u003c\/b\u003e Hardcover\u003cbr\u003e\u003cb\u003eWeight:\u003c\/b\u003e 2.10lbs\u003cbr\u003e\u003cb\u003eSize:\u003c\/b\u003e 10.00h x 7.00w x 0.94d","brand":"Igor Ed. Roninson","offers":[{"title":"Hardcover","offer_id":47420890022143,"sku":"9780306435478","price":99.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0662\/2982\/9887\/files\/img_4127a041-b6ae-4868-abc6-a6eb0d3247cd.jpg?v=1761526451","url":"https:\/\/www.whiterainbookhouse.com\/products\/molecular-and-cellular-biology-of-igor-ed-roninson-9780306435478","provider":"WR Book House","version":"1.0","type":"link"}