{"product_id":"molecular-mechanisms-and-therapies-of-donatella-delle-cave-9783725809516","title":"Molecular Mechanisms and Therapies of Colorectal Cancer 2.0","description":"\u003cp\u003eColorectal cancer (CRC) is currently the third leading cause of cancer-related mortality. Transforming growth factor beta (TGF-β) signaling has been associated with CRC growth and metastasis due to its involvement in proliferation, epithelial-to-mesenchymal transition (EMT), and angiogenesis. The TGF-β superfamily contains over forty members, including TGF-βs, Nodal, Activin, and bone morphogenetic proteins (BMPs). Three types of TGF-β receptors (TGFβRs) have been identified: types 1, 2, and 3. After ligand binding, TGF-βR2 recruits and phosphorylates TGF-βR1, which, in turn, phosphorylates downstream SMAD (small mother against decapentaplegic) proteins. Phosphorylated SMAD4 translocates into the nucleus, where it activates the transcription of numerous target genes (including \u003cem\u003eSERPINE1, LTBP2, CDKN1A, ARID3B, ATXN1, PTPRK, RAB6A, SMAD7, EHBP1\u003c\/em\u003e, etc.), acting predominantly as a tumor suppressor gene. Interestingly, alterations in \u003cem\u003eSMAD4 \u003c\/em\u003eare frequent in metastatic CRC and, together with \u003cem\u003eTGF-βR2 \u003c\/em\u003egene mutations, have been reported as late events able to promote CRC progression. The study of the TGF-β\u003cem\u003e \u003c\/em\u003epathway in metastatic CRC is challenging because of the great genetic heterogeneity of CRC. However, the increasing availability of targeted and whole-exome DNA sequencing techniques makes it possible to identify genetic mutations in complex, dynamic, and heterogeneous clinical contexts and make correlations with clinical outcomes.\u003c\/p\u003e\u003cbr\u003e\u003cbr\u003e\u003cb\u003eAuthor:\u003c\/b\u003e Donatella Delle Cave\u003cbr\u003e\u003cb\u003eISBN-10:\u003c\/b\u003e 3725809518\u003cbr\u003e\u003cb\u003eISBN-13:\u003c\/b\u003e 9783725809516\u003cbr\u003e\u003cb\u003ePublisher:\u003c\/b\u003e Mdpi AG\u003cbr\u003e\u003cb\u003eLanguage:\u003c\/b\u003e English\u003cbr\u003e\u003cb\u003ePublished:\u003c\/b\u003e 05\/30\/2024\u003cbr\u003e\u003cb\u003ePages:\u003c\/b\u003e 186\u003cbr\u003e\u003cb\u003eFormat:\u003c\/b\u003e Hardcover\u003cbr\u003e\u003cb\u003eWeight:\u003c\/b\u003e 1.33lbs\u003cbr\u003e\u003cb\u003eSize:\u003c\/b\u003e 9.61h x 6.69w x 0.63d","brand":"Donatella Delle Cave","offers":[{"title":"Hardcover","offer_id":48113851334911,"sku":"9783725809516","price":76.55,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0662\/2982\/9887\/files\/img_4ca6dcdd-d7e9-4baf-95d2-815730485c2c.jpg?v=1769617567","url":"https:\/\/www.whiterainbookhouse.com\/products\/molecular-mechanisms-and-therapies-of-donatella-delle-cave-9783725809516","provider":"WR Book House","version":"1.0","type":"link"}