{"product_id":"myc-and-the-pathway-to-chi-v-dang-9781621820086","title":"Myc and the Pathway to Cancer","description":"The \u003cem\u003eMYC\u003c\/em\u003e gene family plays essential roles in normal development and in multiple cellular functions. Moreover aberrant \u003cem\u003eMYC \u003c\/em\u003egene activation is profoundly involved in the etiology of a wide range of cancers. \u003cem\u003eMYC\u003c\/em\u003e encodes a transcriptional regulator that modulates expression of genes controlling cell growth, proliferation, metabolism, differentiation, and death. Deregulation of these expression programs has been linked to MYC's function in tumor initiation, progression, and survival. \u003cp\u003e\u003c\/p\u003eWritten and edited by experts in the field, this collection from \u003cem\u003eCold Spring Harbor Perspectives in Medicine\u003c\/em\u003e covers all aspects of \u003cem\u003eMYC\u003c\/em\u003e biology. The contributors discuss its normal functions in the control of cell growth, cell competition, pluripotency, and development, as well as the molecular basis for the effects of the MYC protein on transcription. In addition, they examine how MYC interacts with other proteins, induces apoptosis, and impacts metabolism, genomic stability, and microRNA expression. \u003cp\u003e\u003c\/p\u003eThe authors also provide a detailed analysis of the role of MYC in tumor initiation and progression. Its involvement in cancers such as medulloblastoma, neuroblastoma, and Burkitt's lymphoma is examined, as are the prospects for anti-MYC therapies in cancer treatment. This book is essential reading for all cancer biologists, as well as researchers studying the regulation of gene expression.\u003cbr\u003e\u003cbr\u003e\u003cb\u003eAuthor:\u003c\/b\u003e Chi V. Dang, Robert N. Eisenman\u003cbr\u003e\u003cb\u003eISBN-10:\u003c\/b\u003e 1621820084\u003cbr\u003e\u003cb\u003eISBN-13:\u003c\/b\u003e 9781621820086\u003cbr\u003e\u003cb\u003ePublisher:\u003c\/b\u003e Cold Spring Harbor Laboratory Press\u003cbr\u003e\u003cb\u003eLanguage:\u003c\/b\u003e English\u003cbr\u003e\u003cb\u003ePublished:\u003c\/b\u003e 05\/31\/2014\u003cbr\u003e\u003cb\u003ePages:\u003c\/b\u003e 429\u003cbr\u003e\u003cb\u003eFormat:\u003c\/b\u003e Hardcover\u003cbr\u003e\u003cb\u003eWeight:\u003c\/b\u003e 2.50lbs\u003cbr\u003e\u003cb\u003eSize:\u003c\/b\u003e 10.30h x 7.20w x 0.90d","brand":"Chi V. Dang","offers":[{"title":"Hardcover","offer_id":46838329540863,"sku":"9781621820086","price":135.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0662\/2982\/9887\/files\/img_ded6175d-b840-4a44-bb33-d92ddaff9de5.jpg?v=1746589490","url":"https:\/\/www.whiterainbookhouse.com\/products\/myc-and-the-pathway-to-chi-v-dang-9781621820086","provider":"WR Book House","version":"1.0","type":"link"}