{"product_id":"new-route-to-the-synthesis-najeh-tka-9786207924332","title":"New route to the synthesis of chiral 1,2,4-oxadiazin-5-ones","description":"The research work carried out in this book aims to develop a simple and rapid synthesis route for new chiral derivatives of 1,2,4-oxadiazin-5-ones known for their interesting biological activities.The first part of this book describes the synthesis of a series of optically active α-bromoacids by enantioselective nitrous deamination of natural amino acids. These will subsequently react with thionyl chloride followed by methanol to give the corresponding α-bromoesters.Condensation of these previously prepared α-bromoesters with 1-benzenesulfonylpyrrolidin-2-carboxamidoxime in the presence of two equivalents of sodium hydride offers desired new chiral 1,2,4-oxadiazin-5-ones in good chemical yields.\u003cbr\u003e\u003cbr\u003e\u003cb\u003eAuthor:\u003c\/b\u003e Najeh Tka\u003cbr\u003e\u003cb\u003eISBN-10:\u003c\/b\u003e 6207924339\u003cbr\u003e\u003cb\u003eISBN-13:\u003c\/b\u003e 9786207924332\u003cbr\u003e\u003cb\u003ePublisher:\u003c\/b\u003e Our Knowledge Publishing\u003cbr\u003e\u003cb\u003eLanguage:\u003c\/b\u003e English\u003cbr\u003e\u003cb\u003ePublished:\u003c\/b\u003e 08\/08\/2024\u003cbr\u003e\u003cb\u003ePages:\u003c\/b\u003e 56\u003cbr\u003e\u003cb\u003eFormat:\u003c\/b\u003e Paperback\u003cbr\u003e\u003cb\u003eWeight:\u003c\/b\u003e 0.21lbs\u003cbr\u003e\u003cb\u003eSize:\u003c\/b\u003e 9.00h x 6.00w x 0.13d","brand":"Najeh Tka","offers":[{"title":"Paperback","offer_id":48446474551551,"sku":"9786207924332","price":48.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0662\/2982\/9887\/files\/img_bffd870f-a47f-462b-97da-a776c0f4a64c.jpg?v=1777224879","url":"https:\/\/www.whiterainbookhouse.com\/products\/new-route-to-the-synthesis-najeh-tka-9786207924332","provider":"WR Book House","version":"1.0","type":"link"}