{"product_id":"nf-kb-a-network-hub-controlling-michael-karin-9781936113552","title":"Nf-Kb, a Network Hub Controlling Immunity, Inflammation, and Cancer","description":"NF-kB is a critical signaling molecule in the immune system that regulates cell survival and cell death, lymphocyte responses, and inflammation. Acting as a transcription factor that can receive several inputs, it coordinates distinct gene expression programs in response to a wide variety of stimuli. \u003cbr\u003eWritten and edited by experts in the field, this collection from Cold Spring Harbor Perspectives in Biology includes contributions covering the structure of NF-kB, its DNA-binding activity and specificity, the role of the inhibitor I-kB, and canonical and alternative mechanisms of NF-kB activation. The contributors examine the physiological role of NF-kB in immune cells, as well as its functions in other tissues, such as the nervous system. They also discuss work indicating that NF-kB represents a critical link between inflammation and cancer. Including clinical perspectives on the use of NF-kB inhibitors in cancer therapy and a historical introduction by David Baltimore, in whose lab NF-kB was discovered, this volume is a vital reference for cell and molecular biologists, immunologists, and pathologists interested in regulation of cell function.\u003cbr\u003e\u003cbr\u003e\u003cbr\u003e\u003cb\u003eAuthor:\u003c\/b\u003e Michael Karin\u003cbr\u003e\u003cb\u003eISBN-10:\u003c\/b\u003e 1936113554\u003cbr\u003e\u003cb\u003eISBN-13:\u003c\/b\u003e 9781936113552\u003cbr\u003e\u003cb\u003ePublisher:\u003c\/b\u003e Cold Spring Harbor Laboratory Press\u003cbr\u003e\u003cb\u003eLanguage:\u003c\/b\u003e English\u003cbr\u003e\u003cb\u003ePublished:\u003c\/b\u003e 07\/01\/2011\u003cbr\u003e\u003cb\u003ePages:\u003c\/b\u003e 272\u003cbr\u003e\u003cb\u003eFormat:\u003c\/b\u003e Paperback\u003cbr\u003e\u003cb\u003eWeight:\u003c\/b\u003e 1.30lbs\u003cbr\u003e\u003cb\u003eSize:\u003c\/b\u003e 9.90h x 7.00w x 0.60d","brand":"Michael Karin","offers":[{"title":"Paperback","offer_id":43937594999039,"sku":"9781936113552","price":49.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0662\/2982\/9887\/products\/img_4473b6f5-b9a5-48eb-8a9a-0da60c6346a2.jpg?v=1681430974","url":"https:\/\/www.whiterainbookhouse.com\/products\/nf-kb-a-network-hub-controlling-michael-karin-9781936113552","provider":"WR Book House","version":"1.0","type":"link"}