{"product_id":"of-mice-and-monocytes-chris-bradburne-9783639082975","title":"Of Mice and Monocytes: Anthrax and the Host Genomic Response","description":"Here we investigate anthrax invasion across epithelial monolayers, human monocyte genomic responses, and mouse genomic responses in spleens, lungs, and livers. Differences in response to toxigenic, and non-toxigenic anthrax strains are discussed and described. Interestingly, epithelial monolayers containing human THP-1 cells expressing a macro-phage phenotype showed increased permeability and bacterial invasion than with just epithelial cells alone. In fact, apoptotic pathways and mediators in THP-1 cells appear to be repressed upon challenge by toxigenic strains, and more activated in challenges by non-toxigenic strains. We observed an upregulation of the apoptotic inhibitor cFLAR during toxigenic infection of human monocytes, and a phenotypical delay in apoptosis for the toxigenic strain-challenged cells. In the mouse model, CASH, the mouse homologue of the human cFLAR, is induced and the apoptotic response is suppressed in liver, an organ with a large proportion of monocyte-derived Kupffer cells. These results indicate a role for the delay of cFLAR-mediated apoptosis as a key virulence factor in the disease.\u003cbr\u003e\u003cbr\u003e\u003cb\u003eAuthor:\u003c\/b\u003e Chris Bradburne\u003cbr\u003e\u003cb\u003eISBN-10:\u003c\/b\u003e 3639082974\u003cbr\u003e\u003cb\u003eISBN-13:\u003c\/b\u003e 9783639082975\u003cbr\u003e\u003cb\u003ePublisher:\u003c\/b\u003e VDM Verlag\u003cbr\u003e\u003cb\u003eLanguage:\u003c\/b\u003e English\u003cbr\u003e\u003cb\u003ePublished:\u003c\/b\u003e 12\/04\/2008\u003cbr\u003e\u003cb\u003ePages:\u003c\/b\u003e 124\u003cbr\u003e\u003cb\u003eFormat:\u003c\/b\u003e Paperback\u003cbr\u003e\u003cb\u003eWeight:\u003c\/b\u003e 0.39lbs\u003cbr\u003e\u003cb\u003eSize:\u003c\/b\u003e 9.00h x 6.00w x 0.26d","brand":"Chris Bradburne","offers":[{"title":"Paperback","offer_id":47424581402879,"sku":"9783639082975","price":63.72,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0662\/2982\/9887\/files\/img_ba0eeacb-a263-4aad-94f7-21f1f423764e.jpg?v=1761531181","url":"https:\/\/www.whiterainbookhouse.com\/products\/of-mice-and-monocytes-chris-bradburne-9783639082975","provider":"WR Book House","version":"1.0","type":"link"}