{"product_id":"optimization-in-drug-discovery-gary-w-caldwell-9781627037419","title":"Optimization in Drug Discovery: In Vitro Methods","description":"\u003cp\u003eThoroughly revised and updated, \u003ci\u003eOptimization in Drug Discovery: In Vitro Methods, Second Edition\u003c\/i\u003e presents a wide spectrum of in vitro assays including formulation, plasma binding, absorption and permeability, cytochrome P450 (CYP) and UDP-glucuronosyltransferases (UGT) metabolism, CYP inhibition and induction, drug transporters, drug-drug interactions via assessment of reactive metabolites, genotoxicity, and chemical and photo-mutagenicity assays. Written for the \u003ci\u003eMethods in Pharmacology and Toxicology\u003c\/i\u003e series, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible protocols, and tips on troubleshooting and avoiding known pitfalls. Expert authors have developed and utilized these in vitro assays to achieve \"drug-like\" characteristics in addition to efficacy properties and good safety profiles of drug candidates.\u003c\/p\u003e\u003cp\u003eComprehensive and up-to-date, \u003ci\u003eOptimization in Drug Discovery: In Vitro Methods, Second Edition\u003c\/i\u003e aims to guide researchers down the difficult path to successful drug discovery and development.\u003c\/p\u003e\u003cbr\u003e\u003cbr\u003e\u003cb\u003eAuthor:\u003c\/b\u003e Gary W. Caldwell\u003cbr\u003e\u003cb\u003eISBN-10:\u003c\/b\u003e 1627037411\u003cbr\u003e\u003cb\u003eISBN-13:\u003c\/b\u003e 9781627037419\u003cbr\u003e\u003cb\u003ePublisher:\u003c\/b\u003e Humana\u003cbr\u003e\u003cb\u003eLanguage:\u003c\/b\u003e English\u003cbr\u003e\u003cb\u003ePublished:\u003c\/b\u003e 11\/09\/2013\u003cbr\u003e\u003cb\u003ePages:\u003c\/b\u003e 597\u003cbr\u003e\u003cb\u003eFormat:\u003c\/b\u003e Hardcover\u003cbr\u003e\u003cb\u003eWeight:\u003c\/b\u003e 2.70lbs\u003cbr\u003e\u003cb\u003eSize:\u003c\/b\u003e 10.10h x 7.20w x 1.50d","brand":"Gary W. Caldwell","offers":[{"title":"Hardcover","offer_id":48485692276991,"sku":"9781627037419","price":219.99,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0662\/2982\/9887\/files\/img_ac6c7a21-2139-4d59-9c01-997929d678aa.jpg?v=1778050930","url":"https:\/\/www.whiterainbookhouse.com\/products\/optimization-in-drug-discovery-gary-w-caldwell-9781627037419","provider":"WR Book House","version":"1.0","type":"link"}