{"product_id":"optimization-of-therapeutic-strategies-for-gregory-g-seaman-9781025130729","title":"Optimization of Therapeutic Strategies for Organophosphate Poisoning","description":"\u003cp\u003eThe National Preparedness Vision requires the U.S. be prepared to prevent, protect against, respond to, and recover from all hazards associated with a chemical attack. Results of this study demonstrate that we cannot protect service members and first responders as required following a nerve agent attack. The research presented herein aimed to construct a physiologically based pharmacokinetic model to determine optimal therapeutic strategies for organophosphate (nerve agent) poisoning. The constructed model integrated organophosphates and two antidotes, atropine and oximes. Model results reasonably mirrored literature data and anecdotal observations of organophosphate poisoning. Results suggest a symptoms-based dosing strategy of atropine and a time-based dosing strategy of oximes. For patients severely poisoned with organophosphorus nerve agents, model results support documented claims of oxime's inefficacy and tendency to heighten the severity of poisoning. The results strongly indicate that military personnel attacked with nerve agents are at a significant health risk if they employ their prescribed treatment as current doctrine dictates. Results presented herein suggest that oxime use be discontinued as currently prescribed within the context of nerve agent exposure; its use will not alter the effects of nerve agent exposure and may increase the adverse effects.\u003c\/p\u003e\u003cp\u003eThis work has been selected by scholars as being culturally important, and is part of the knowledge base of civilization as we know it. This work was reproduced from the original artifact, and remains as true to the original work as possible. Therefore, you will see the original copyright references, library stamps (as most of these works have been housed in our most important libraries around the world), and other notations in the work.\u003c\/p\u003e\u003cp\u003eThis work is in the public domain in the United States of America, and possibly other nations. Within the United States, you may freely copy and distribute this work, as no entity (individual or corporate) has a copyright on the body of the work.\u003c\/p\u003e\u003cp\u003eAs a reproduction of a historical artifact, this work may contain missing or blurred pages, poor pictures, errant marks, etc. Scholars believe, and we concur, that this work is important enough to be preserved, reproduced, and made generally available to the public. We appreciate your support of the preservation process, and thank you for being an important part of keeping this knowledge alive and relevant.\u003c\/p\u003e\u003cbr\u003e\u003cbr\u003e\u003cbr\u003e\u003cb\u003eAuthor:\u003c\/b\u003e Gregory G. Seaman\u003cbr\u003e\u003cb\u003eISBN-10:\u003c\/b\u003e 1025130723\u003cbr\u003e\u003cb\u003eISBN-13:\u003c\/b\u003e 9781025130729\u003cbr\u003e\u003cb\u003ePublisher:\u003c\/b\u003e Hutson Street Press\u003cbr\u003e\u003cb\u003eLanguage:\u003c\/b\u003e English\u003cbr\u003e\u003cb\u003ePublished:\u003c\/b\u003e 05\/22\/2025\u003cbr\u003e\u003cb\u003ePages:\u003c\/b\u003e 88\u003cbr\u003e\u003cb\u003eFormat:\u003c\/b\u003e Paperback\u003cbr\u003e\u003cb\u003eWeight:\u003c\/b\u003e 0.30lbs\u003cbr\u003e\u003cb\u003eSize:\u003c\/b\u003e 9.21h x 6.14w x 0.18d","brand":"Gregory G. Seaman","offers":[{"title":"Paperback","offer_id":47425637449983,"sku":"9781025130729","price":15.95,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0662\/2982\/9887\/files\/img_aaa0d9b1-34bc-4b37-bac1-633bc3f30863.jpg?v=1761540588","url":"https:\/\/www.whiterainbookhouse.com\/products\/optimization-of-therapeutic-strategies-for-gregory-g-seaman-9781025130729","provider":"WR Book House","version":"1.0","type":"link"}