{"product_id":"origin-and-evolution-of-telomeres-jozef-nosek-9781587063091","title":"Origin and Evolution of Telomeres","description":"\u003cp\u003eLinear chromosomes represent an evolutionary innovation associated with the origin of eukaryotic cells. This book describes how linear chromosomes and primordial pathways for maintaining their terminal structures, telomeres, emerged in early eukaryotes. \u003cbr\u003eTelomeres, derived from the Greek meaning terminal part, were first described by Hermann Muller in 1938. Telomeres are specialized structures that comprise the ends of linear chromosomes in eukaryotes. Linearity is crucial for chromosome pairing during meiosis and sexual reproduction. \u003cbr\u003eInspired by Dobzhansky's dictum that \"nothing in biology makes sense except in the light of evolution\", this book brings together information about the origin and evolution of telomeres, their functions and the consequences of eukaryotic linearity which is an essential prerequisite of meiotic cell division and sexual reproduction. Selective pressure toward linearization must have been associated with the emergence of robust and redundant mechanisms for the maintenance of telomeres. These pathways comprise a molecular clock involved in cell senescence, carcinogenesis and immortalization.\u003c\/p\u003e\u003cbr\u003e\u003cbr\u003e\u003cb\u003eAuthor:\u003c\/b\u003e Jozef Nosek,Lubomir Tomaska\u003cbr\u003e\u003cb\u003eISBN-10:\u003c\/b\u003e 1587063093\u003cbr\u003e\u003cb\u003eISBN-13:\u003c\/b\u003e 9781587063091\u003cbr\u003e\u003cb\u003ePublisher:\u003c\/b\u003e CRC Press\u003cbr\u003e\u003cb\u003eLanguage:\u003c\/b\u003e English\u003cbr\u003e\u003cb\u003ePublished:\u003c\/b\u003e 05\/26\/2008\u003cbr\u003e\u003cb\u003ePages:\u003c\/b\u003e 194\u003cbr\u003e\u003cb\u003eFormat:\u003c\/b\u003e Hardcover","brand":"Jozef Nosek","offers":[{"title":"Hardcover","offer_id":48065722810623,"sku":"9781587063091","price":200.0,"currency_code":"USD","in_stock":false}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0662\/2982\/9887\/files\/img_cb3e81d4-5662-484f-a9c2-8d52f32c7da8.jpg?v=1768676828","url":"https:\/\/www.whiterainbookhouse.com\/products\/origin-and-evolution-of-telomeres-jozef-nosek-9781587063091","provider":"WR Book House","version":"1.0","type":"link"}