{"product_id":"pharmacokinetic-pharmacodynamic-pkpd-modelling-dheeraj-gopu-9783659129186","title":"Pharmacokinetic \/ Pharmacodynamic (PK\/PD) Modelling","description":"Pharmacokinetic-Pharmacodynamic (PK\/PD) modeling is scientific mathematical tool which integrates relationship PK model to that of PD model and a statistical model (particularly, the intra- and inter-individual variability of PK and\/or PD origin). PK-PD approach is used from initial preclinical stage to last clinical phases for exploring the concentration-effect relationships executed using various approaches, such as steady state concentrations versus non-steady state concentrations models and parametric versus nonparametric models. Basing on the concentration-response invariant data basic models such as fixed-effect, linear, log-linear, Emax and sigmaoid Emax models are used. But in case of time-concentration and time-response variant conditions effect compartment, acute tolerance, sensitization and physiological indirect response models have been used. PK\/PD modeling can be used as an applied science tool to provide answers on efficacy and safety of new drugs faster and at a lower cost. Still limits of PK\/PD approaches include the development of appropriate models, the validity of surrogate endpoints, and the acceptance of these models in a regulatory environment.\u003cbr\u003e\u003cbr\u003e\u003cb\u003eAuthor:\u003c\/b\u003e Dheeraj Gopu\u003cbr\u003e\u003cb\u003eISBN-10:\u003c\/b\u003e 3659129186\u003cbr\u003e\u003cb\u003eISBN-13:\u003c\/b\u003e 9783659129186\u003cbr\u003e\u003cb\u003ePublisher:\u003c\/b\u003e LAP Lambert Academic Publishing\u003cbr\u003e\u003cb\u003eLanguage:\u003c\/b\u003e English\u003cbr\u003e\u003cb\u003ePublished:\u003c\/b\u003e 05\/26\/2012\u003cbr\u003e\u003cb\u003ePages:\u003c\/b\u003e 92\u003cbr\u003e\u003cb\u003eFormat:\u003c\/b\u003e Paperback\u003cbr\u003e\u003cb\u003eWeight:\u003c\/b\u003e 0.32lbs\u003cbr\u003e\u003cb\u003eSize:\u003c\/b\u003e 9.00h x 6.00w x 0.22d","brand":"Dheeraj Gopu","offers":[{"title":"Paperback","offer_id":44966385680639,"sku":"9783659129186","price":52.92,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0662\/2982\/9887\/files\/img_65e4a34b-d6b0-41c6-8008-21c765f3d0e8.jpg?v=1711159696","url":"https:\/\/www.whiterainbookhouse.com\/products\/pharmacokinetic-pharmacodynamic-pkpd-modelling-dheeraj-gopu-9783659129186","provider":"WR Book House","version":"1.0","type":"link"}