{"product_id":"phenotyping-of-human-ipsc-derived-neurons-elizabeth-d-buttermore-9780128222775","title":"Phenotyping of Human Ipsc-Derived Neurons: Patient-Driven Research","description":"\u003cp\u003e\u003ci\u003ePhenotyping of Human iPSC-derived Neurons: Patient-Driven Research\u003c\/i\u003e examines the steps in a preclinical pipeline that utilizes iPSC-derived neuronal technology to better understand neurological disorders and identify novel therapeutics, also providing considerations and best practices. By presenting example projects that identify phenotypes and mechanisms relevant to autism spectrum disorder and epilepsy, this book allows readers to understand what considerations are important to assess at the start of project design. Sections address reproducibility issues and advances in technology at each stage of the pipeline and provide suggestions for improvement. From patient sample collection and proper controls to neuronal differentiation, phenotyping, screening, and considerations for moving to the clinic, these detailed descriptions of each stage of the pipeline will help everyone, regardless of stage in the pipeline.\u003c\/p\u003e \u003cp\u003eIn recent years, drug discovery in the neurosciences has struggled to identify novel therapeutics for patients with varying indications, including epilepsy, chronic pain, and psychosis. Current treatment options for such patients are decades old and offer little relief with many side effects. One explanation for this lull in novel therapeutics is a lack of novel target identification for neurological disorders (and target identification requires exemplar preclinical data). To improve on the preclinical work that often relies on rodent modeling, the field has begun utilizing patient-derived induced pluripotent stem cells (iPSCs) to differentiate neurons in vitro for preclinical characterization of neurological disease and target identification.\u003c\/p\u003e\u003cbr\u003e\u003cbr\u003e\u003cb\u003eAuthor:\u003c\/b\u003e Elizabeth D. Buttermore\u003cbr\u003e\u003cb\u003eISBN-10:\u003c\/b\u003e 0128222778\u003cbr\u003e\u003cb\u003eISBN-13:\u003c\/b\u003e 9780128222775\u003cbr\u003e\u003cb\u003ePublisher:\u003c\/b\u003e Academic Press\u003cbr\u003e\u003cb\u003eLanguage:\u003c\/b\u003e English\u003cbr\u003e\u003cb\u003ePublished:\u003c\/b\u003e 09\/15\/2022\u003cbr\u003e\u003cb\u003ePages:\u003c\/b\u003e 372\u003cbr\u003e\u003cb\u003eFormat:\u003c\/b\u003e Paperback","brand":"Elizabeth D. Buttermore","offers":[{"title":"Paperback","offer_id":44076421251327,"sku":"9780128222775","price":150.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0662\/2982\/9887\/files\/img_173d37a0-558c-49c0-aa00-47f2923d7d81.jpg?v=1685464896","url":"https:\/\/www.whiterainbookhouse.com\/products\/phenotyping-of-human-ipsc-derived-neurons-elizabeth-d-buttermore-9780128222775","provider":"WR Book House","version":"1.0","type":"link"}