{"product_id":"physiological-consequences-of-brain-insulin-andr-kleinridders-9780367529482","title":"Physiological Consequences of Brain Insulin Action","description":"\u003cp\u003eThe brain is crucial for the regulation of whole-body metabolism and behavior. The pancreas-derived hormone insulin modulates brain function and affects energy metabolism as well as cognition. This is partially achieved by modulating several types of brain cell populations including those relevant to satiety and reward. Importantly, brains of Alzheimer s disease patients exhibit a signature of brain insulin resistance with perturbed brain metabolism. This book will cover the basics of insulin signaling in the brain and will describe concepts of insulin resistance, a feature of type 2 diabetes. Moreover insulin s effect on cognitive function will be pointed out and the association between brain insulin resistance and neurodegenerative diseases discussed. Additionally, potential behavioral and pharmacological concepts which can affect brain insulin signaling will be summarized.\u003c\/p\u003e \u003cp\u003e\u003cstrong\u003eKey Features: \u003c\/strong\u003e\u003c\/p\u003e \u003cul\u003e \u003cp\u003e \u003c\/p\u003e\n\u003cli\u003eSummarizes insulin and the closely related IGF-1 receptor signaling \u003c\/li\u003e \u003cp\u003e\u003c\/p\u003e \u003cp\u003e \u003c\/p\u003e\n\u003cli\u003eDepicts concepts of insulin resistance \u003c\/li\u003e \u003cp\u003e\u003c\/p\u003e \u003cp\u003e \u003c\/p\u003e\n\u003cli\u003eHighlights the importance of conserved brain insulin signaling for brain function, metabolism, and behavior\u003c\/li\u003e \u003cp\u003e\u003c\/p\u003e \u003cp\u003e \u003c\/p\u003e\n\u003cli\u003eDescribes potential behavioral and pharmacological approaches to support brain insulin signaling\u003c\/li\u003e \u003cp\u003e\u003c\/p\u003e\n\u003c\/ul\u003e\u003cbr\u003e\u003cbr\u003e\u003cb\u003eAuthor:\u003c\/b\u003e André Kleinridders\u003cbr\u003e\u003cb\u003eISBN-10:\u003c\/b\u003e 0367529483\u003cbr\u003e\u003cb\u003eISBN-13:\u003c\/b\u003e 9780367529482\u003cbr\u003e\u003cb\u003ePublisher:\u003c\/b\u003e CRC Press\u003cbr\u003e\u003cb\u003eLanguage:\u003c\/b\u003e English\u003cbr\u003e\u003cb\u003ePublished:\u003c\/b\u003e 09\/06\/2022\u003cbr\u003e\u003cb\u003ePages:\u003c\/b\u003e 244\u003cbr\u003e\u003cb\u003eFormat:\u003c\/b\u003e Hardcover\u003cbr\u003e\u003cb\u003eWeight:\u003c\/b\u003e 1.52lbs\u003cbr\u003e\u003cb\u003eSize:\u003c\/b\u003e 10.00h x 7.00w x 0.63d","brand":"André Kleinridders","offers":[{"title":"Hardcover","offer_id":44070699860223,"sku":"9780367529482","price":170.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0662\/2982\/9887\/files\/img_4ce0785d-9172-4bc7-b035-4964b7479bfc.jpg?v=1685431850","url":"https:\/\/www.whiterainbookhouse.com\/products\/physiological-consequences-of-brain-insulin-andr-kleinridders-9780367529482","provider":"WR Book House","version":"1.0","type":"link"}