{"product_id":"progress-in-medicinal-chemistry-f-d-king-9780444509598","title":"Progress in Medicinal Chemistry: Volume 39","description":"\u003cp\u003eThis volume covers contemporary advances in five important areas of pharmacology and medicinal chemistry including: a comprehensive account of inhibitors of the caspase family of proteolytic enzymes that represent a new class of anti-inflammatory and antiapoptotic agents of potential value in rheumatoid arthritis, and other peripheral and central indications; adoc umented survey of semi-synthetic and totally synthetic antibiotics and anti HIV agents and their sites of interaction; inhibitors of the intracellular enzyme acyl-CoA: cholesterol O-acyltransferase (ACAT) developed for the treatment of hypercholesterolemia; and recent progress in growth hormone secretagogues, with the focus on strategies to improve oral bioavailability and duration of action. Inhibition of the proteolytic enzyme, hepatitis C protease N-3(NS3), required for viral replication, is one of the most attractive targets for HCV infections. Progress and prospects in the design of peptide and non-peptide inhibitors are described here. design and clinical potential of new drug molecules; valuable summaries of structure-activity relationships in topical areas of medicinal chemistry; and extensive references to the biology, medicinal chemistry and clinical aspects of each topic.\u003c\/p\u003e\u003cbr\u003e\u003cbr\u003e\u003cb\u003eAuthor:\u003c\/b\u003e F. D. King\u003cbr\u003e\u003cb\u003eISBN-10:\u003c\/b\u003e 0444509593\u003cbr\u003e\u003cb\u003eISBN-13:\u003c\/b\u003e 9780444509598\u003cbr\u003e\u003cb\u003ePublisher:\u003c\/b\u003e Elsevier Science\u003cbr\u003e\u003cb\u003eLanguage:\u003c\/b\u003e English\u003cbr\u003e\u003cb\u003ePublished:\u003c\/b\u003e 04\/24\/2002\u003cbr\u003e\u003cb\u003ePages:\u003c\/b\u003e 273\u003cbr\u003e\u003cb\u003eFormat:\u003c\/b\u003e Hardcover\u003cbr\u003e\u003cb\u003eWeight:\u003c\/b\u003e 1.10lbs\u003cbr\u003e\u003cb\u003eSize:\u003c\/b\u003e 8.44h x 5.82w x 0.66d","brand":"F. D. King","offers":[{"title":"Hardcover","offer_id":48135876673791,"sku":"9780444509598","price":210.0,"currency_code":"USD","in_stock":false}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0662\/2982\/9887\/files\/img_169d8c6f-a2b3-48ab-a3a2-72ce1e7d0ea0.jpg?v=1770159037","url":"https:\/\/www.whiterainbookhouse.com\/products\/progress-in-medicinal-chemistry-f-d-king-9780444509598","provider":"WR Book House","version":"1.0","type":"link"}