{"product_id":"protein-homeostasis-second-edition-jeffery-w-kelly-9781621822967","title":"Protein Homeostasis, Second Edition","description":"The entire life cycle of a protein-from synthesis and folding to transport and degradation-is carefully controlled by the proteostasis network. This network, consisting of many interconnected pathways and processes, manages protein homeostasis by dynamically responding to the needs of the cell. Stress and aging can challenge the proteostasis network, resulting in the aggregation of misfolded proteins-a feature of numerous neurodegenerative conditions. \u003cp\u003e\u003c\/p\u003eWritten and edited by experts in the field, this collection from \u003cem\u003eCold Spring Harbor Perspectives in Biology \u003c\/em\u003eprovides a comprehensive update on how the proteostasis network functions in healthy cells and the diseases that result when protein quality control goes awry. The contributors examine the relevant biochemical attributes of proteins (e.g., solubility), the functions of normal protein aggregates (e.g., biofilm formation in bacteria), and the various heat shock proteins, chaperones, translocation machineries, proteasomes, signaling factors, and transcriptional programs involved in proteostasis. The roles of specific subcellular structures-the endoplasmic reticulum, mitochondria, ribosomes, lysosomes, and cytoplasm-in protein quality control are covered, as is the regulation of proteostasis at the organismal level (e.g., via neuronal activity). \u003cp\u003e\u003c\/p\u003eDiscussions of the responses by cells when errors in protein quality control occur, the medical disorders that can result (e.g., Alzheimer disease), and pharmacologic approaches to ameliorate protein conformational disorders are also included. This book is therefore an essential reference for biochemists, cell biologists, and all biomedical scientists wishing to understand the pathological consequences of and potential therapies for proteostasis deficiencies in common human diseases.\u003cbr\u003e\u003cbr\u003e\u003cb\u003eAuthor:\u003c\/b\u003e Jeffery W. Kelly, Richard Morimoto\u003cbr\u003e\u003cb\u003eISBN-10:\u003c\/b\u003e 1621822966\u003cbr\u003e\u003cb\u003eISBN-13:\u003c\/b\u003e 9781621822967\u003cbr\u003e\u003cb\u003ePublisher:\u003c\/b\u003e Cold Spring Harbor Laboratory Press\u003cbr\u003e\u003cb\u003eLanguage:\u003c\/b\u003e English\u003cbr\u003e\u003cb\u003ePublished:\u003c\/b\u003e 06\/30\/2019\u003cbr\u003e\u003cb\u003ePages:\u003c\/b\u003e 562\u003cbr\u003e\u003cb\u003eFormat:\u003c\/b\u003e Hardcover\u003cbr\u003e\u003cb\u003eWeight:\u003c\/b\u003e 3.00lbs\u003cbr\u003e\u003cb\u003eSize:\u003c\/b\u003e 10.30h x 7.30w x 1.30d\u003cbr\u003e\u003cbr\u003e\u003cb\u003eReview Citation(s): \u003c\/b\u003e\u003cbr\u003e\u003ci\u003eChoice\u003c\/i\u003e 07\/01\/2020","brand":"Jeffery W. Kelly","offers":[{"title":"Hardcover","offer_id":43984678224127,"sku":"9781621822967","price":33.75,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0662\/2982\/9887\/files\/img_3f04082c-877d-447a-adad-de0c9f3c937f.jpg?v=1683273631","url":"https:\/\/www.whiterainbookhouse.com\/products\/protein-homeostasis-second-edition-jeffery-w-kelly-9781621822967","provider":"WR Book House","version":"1.0","type":"link"}