{"product_id":"quantitative-analysis-of-cellular-drug-gus-r-rosania-9781071612491","title":"Quantitative Analysis of Cellular Drug Transport, Disposition, and Delivery","description":"\u003cp\u003e\u003cb\u003ePart I: Small Molecules\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e\u003cb\u003e \u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e\u003cb\u003e1. Measurement of Transcellular Transport Rates and Intracellular Drug Sequestration in the Presence of an Extracellular Concentration Gradient\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e Kyoung Ah Min and Gus R. Rosania\u003c\/p\u003e \u003cp\u003e \u003c\/p\u003e \u003cp\u003e\u003cb\u003e2. Kinetic Design for Establishing Long Term Stationary Cytosol Concentrations during Drug Transport across P-gp Expressing Confluent Cell Monolayers to Facilitate Measuring Cytosol Concentration, Fitting Drug Molar Partition Coefficients into the Cytosolic Monolayer of the Plasma Membrane and Kinetically Identifying Drug Uptake Transporters\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e Joe Bentz\u003c\/p\u003e \u003cp\u003e \u003c\/p\u003e \u003cp\u003e\u003cb\u003e3. In Vitro Methodologies to Assess Potential for Transporter-Mediated Drug-Drug Interactions\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e Jibin Li, Qing Wang, and Ismael J. Hidalgo\u003c\/p\u003e \u003cp\u003e\u003c\/p\u003e \u003cp\u003e\u003cb\u003e4. Determination of Fraction Unbound and Unbound Partition Coefficient to Estimate Intracellular Free Drug Concentration\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e Sangwoo Ryu, Keith Riccardi, Samantha Jordan, Nathaniel Johnson, and Li Di\u003c\/p\u003e \u003cp\u003e \u003c\/p\u003e \u003cp\u003e\u003cb\u003e5. Quantitative Analysis of Intracellular Drug Concentrations in Hepatocytes\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e Chitra Saran, James J. Beaudoin, Nathan D. Pfeifer, and Kim L.R. Brouwer\u003c\/p\u003e \u003cp\u003e \u003c\/p\u003e \u003cp\u003e\u003cb\u003e6. Quantification of Intracellular Drug Aggregates and Precipitates\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e Phillip Rzeczycki and Gus R. Rosania\u003c\/p\u003e \u003cp\u003e \u003c\/p\u003e \u003cp\u003e\u003cb\u003e7. Quantitative Phenotypic Analysis of Drug Sequestering Macrophage Subpopulations\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e Mikhail D. Murashov\u003c\/p\u003e \u003cp\u003e \u003c\/p\u003e \u003cp\u003e\u003cb\u003e8. \u003c\/b\u003e\u003cb\u003eUsing an Integrated QSAR Model to Check Whether Small-Molecule Xenobiotics Will Accumulate in Biomembranes, with Particular Reference to Fluorescent Imaging Probes\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e Richard W. Horobin and Juan C. Stockert\u003c\/p\u003e \u003cp\u003e \u003c\/p\u003e \u003cp\u003e\u003cb\u003e9. Diversity-Oriented Fluorescence Library Approach (DOFLA) for Discovery of Cell-Permeable Probes for Applications in Live Cell Imaging\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e Dongdong Su and Young-Tae Chang\u003c\/p\u003e \u003cp\u003e\u003c\/p\u003e \u003cp\u003e\u003cb\u003ePart II: Macromolecules, Biologics, and Nanoparticles\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e\u003cb\u003e \u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e\u003cb\u003e10. Overcoming Cellular and Systemic Barriers to Design the Next Wave of Peptide Therapeutics\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e Jerome Hochman, Tomi Sawyer, and Ruchia Duggal\u003c\/p\u003e \u003cp\u003e\u003c\/p\u003e \u003cp\u003e\u003cb\u003e11. Intracellular Targeting of Cyclotides for Therapeutic Applications\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e Nicole Lawrence and David J. Craik\u003c\/p\u003e \u003cp\u003e \u003c\/p\u003e \u003cp\u003e\u003cb\u003e12. Cellular Trafficking of Monoclonal and Bispecific Antibodies\u003c\/b\u003e\u003c\/p\u003e John J. Rhoden and Christopher M. Wiethoff\u003cp\u003e\u003c\/p\u003e \u003cp\u003e\u003cb\u003e \u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e\u003cb\u003e13. Quantitative Drug Target Imaging Using Paired-Agent Principles\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e Kenneth M. Tichauer, Negar Sadeghipour, Yu \"Winston\" Wang, Summer L. Gibbs, Jonathan T.C. Liu, and Kimberley S. Samkoe\u003c\/p\u003e \u003cp\u003e \u003c\/p\u003e \u003cp\u003e\u003cb\u003e14. Quantitative Determination of Intracellular Bond Cleavage\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e Joshua A. Walker, Michelle R. Sorkin, and Christopher A. Alabi\u003c\/p\u003e \u003cp\u003e \u003c\/p\u003e \u003cp\u003e\u003cb\u003e15. Development and Application of a Single Cell-Level PK-PD Model for ADCs\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e\u0026amp;nb...\u003cbr\u003e\u003cbr\u003e\u003cb\u003eAuthor:\u003c\/b\u003e Gus R. Rosania\u003cbr\u003e\u003cb\u003eISBN-10:\u003c\/b\u003e 1071612492\u003cbr\u003e\u003cb\u003eISBN-13:\u003c\/b\u003e 9781071612491\u003cbr\u003e\u003cb\u003ePublisher:\u003c\/b\u003e Humana\u003cbr\u003e\u003cb\u003eLanguage:\u003c\/b\u003e English\u003cbr\u003e\u003cb\u003ePublished:\u003c\/b\u003e 06\/08\/2021\u003cbr\u003e\u003cb\u003ePages:\u003c\/b\u003e 453\u003cbr\u003e\u003cb\u003eFormat:\u003c\/b\u003e Hardcover\u003cbr\u003e\u003cb\u003eWeight:\u003c\/b\u003e 2.20lbs\u003cbr\u003e\u003cb\u003eSize:\u003c\/b\u003e 10.20h x 7.70w x 1.10d\u003c\/p\u003e","brand":"Gus R. Rosania","offers":[{"title":"Hardcover","offer_id":44129883291903,"sku":"9781071612491","price":199.99,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0662\/2982\/9887\/files\/img_a3048680-f87e-49ca-aacc-dcdd08faf678.jpg?v=1687466336","url":"https:\/\/www.whiterainbookhouse.com\/products\/quantitative-analysis-of-cellular-drug-gus-r-rosania-9781071612491","provider":"WR Book House","version":"1.0","type":"link"}