{"product_id":"quantitative-drug-design-yvonne-c-martin-9781420070996","title":"Quantitative Drug Design: A Critical Introduction","description":"\u003cp\u003eSince the publication of the first edition, the field has changed dramatically. Scientists can now explicitly consider 3D features in quantitative structure-activity relationship (QSAR) studies and often have the 3D structure of the macromolecular target to guide the 3D QSAR. Improvements in computer hardware and software have also made the methods more accessible to scientists. Taking these developments into account, \u003cstrong\u003eQuantitative Drug Design\u003c\/strong\u003e\u003cstrong\u003e: A Critical Introduction, Second Edition\u003c\/strong\u003e shows scientists how to apply QSAR techniques at a state-of-the-art level.\u003c\/p\u003e\u003cp\u003e\u003c\/p\u003e\u003cp\u003e\u003cstrong\u003eNew to the Second Edition\u003c\/strong\u003e\u003c\/p\u003e\u003cp\u003e\u003c\/p\u003e\u003cul\u003e \u003cp\u003e\u003c\/p\u003e\n\u003cp\u003e\u003c\/p\u003e \u003cli\u003eA new chapter on methods that identify the 3D conformations to use for 3D QSAR\u003c\/li\u003e \u003cp\u003e\u003c\/p\u003e\n\u003cli\u003eNew discussions on partial least squares, multidimensional scaling, clustering, support vector machines, kNN potency prediction, and recursive partitioning\u003c\/li\u003e \u003cp\u003e\u003c\/p\u003e\n\u003cli\u003eExpanded case studies that include the results of data that has been re-analyzed using newer methods\u003c\/li\u003e \u003cp\u003e\u003c\/p\u003e\n\u003cli\u003eA new case study on the discovery of novel dopaminergics with pharmacophore mapping and CoMFA\u003c\/li\u003e \u003cp\u003e\u003c\/p\u003e\n\u003cli\u003eA new case study on the application of CoMFA to series in which the 3D structure of the ligand-protein complex is known\u003c\/li\u003e \u003cp\u003e\u003c\/p\u003e \u003c\/ul\u003e\u003cp\u003e\u003c\/p\u003e\u003cp\u003eBased on the author's four decades of experience in all areas of ligand-based computer-assisted drug design, this invaluable book describes how to transform ligand structure-activity relationships into models that predict the potency or activity\/inactivity of new molecules. It will help you avoid traps when dealing with quantitative drug design.\u003c\/p\u003e\u003cp\u003e\u003c\/p\u003e\u003cbr\u003e\u003cbr\u003e\u003cb\u003eAuthor:\u003c\/b\u003e Yvonne C. Martin\u003cbr\u003e\u003cb\u003eISBN-10:\u003c\/b\u003e 1420070991\u003cbr\u003e\u003cb\u003eISBN-13:\u003c\/b\u003e 9781420070996\u003cbr\u003e\u003cb\u003ePublisher:\u003c\/b\u003e CRC Press\u003cbr\u003e\u003cb\u003eLanguage:\u003c\/b\u003e English\u003cbr\u003e\u003cb\u003ePublished:\u003c\/b\u003e 05\/03\/2010\u003cbr\u003e\u003cb\u003ePages:\u003c\/b\u003e 304\u003cbr\u003e\u003cb\u003eFormat:\u003c\/b\u003e Hardcover\u003cbr\u003e\u003cb\u003eWeight:\u003c\/b\u003e 1.15lbs\u003cbr\u003e\u003cb\u003eSize:\u003c\/b\u003e 9.30h x 6.40w x 0.90d","brand":"Yvonne C. Martin","offers":[{"title":"Hardcover","offer_id":48113499963647,"sku":"9781420070996","price":255.0,"currency_code":"USD","in_stock":false}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0662\/2982\/9887\/files\/img_226a6aad-fb38-43c9-ae82-59a8af25d05e.jpg?v=1769615434","url":"https:\/\/www.whiterainbookhouse.com\/products\/quantitative-drug-design-yvonne-c-martin-9781420070996","provider":"WR Book House","version":"1.0","type":"link"}