{"product_id":"regulation-of-cancer-immune-checkpoints-jie-xu-9789811532658","title":"Regulation of Cancer Immune Checkpoints: Molecular and Cellular Mechanisms and Therapy","description":"Introduction.- Molecular and cellular functions of CTLA-4 pathway.- Roles of PD-1\/PD-L1 pathway: signaling, cancer, and beyond.- Discovery of new immune checkpoints: family grows up.- Mechanisms of resistance to checkpoint blockade therapy.- Molecular events behind adverse effects.- Rational discovery of response biomarkers.- Spatiotemporal changes in checkpoint molecule expression.- Functions of checkpoint molecules beyond immune evasion.- Genetic alterations and checkpoint expression.- Regulations on messenger RNA: wires and nodes.- Folded or degraded in endoplasmic reticulum.- Mono- and poly-ubiquitination: tags for fates.- Lysosome as the black hole for checkpoint molecules.- Phosphorylation: a fast switch for checkpoint signalling.- Palmitoylation as a signal for delivery.- Checkpoints under traffic control: from and to organelles.- Exosome and secretion: action on?.- Macromolecules and antibody-based drugs.- Mechanisms inspired targeting peptides.- Small molecular inhibitors.- Therapeutic development of immune checkpoint blockers.- Concluding remarks\u003cbr\u003e\u003cbr\u003e\u003cb\u003eAuthor:\u003c\/b\u003e Jie Xu\u003cbr\u003e\u003cb\u003eISBN-10:\u003c\/b\u003e 9811532656\u003cbr\u003e\u003cb\u003eISBN-13:\u003c\/b\u003e 9789811532658\u003cbr\u003e\u003cb\u003ePublisher:\u003c\/b\u003e Springer\u003cbr\u003e\u003cb\u003eLanguage:\u003c\/b\u003e English\u003cbr\u003e\u003cb\u003ePublished:\u003c\/b\u003e 03\/18\/2020\u003cbr\u003e\u003cb\u003ePages:\u003c\/b\u003e 653\u003cbr\u003e\u003cb\u003eFormat:\u003c\/b\u003e Hardcover\u003cbr\u003e\u003cb\u003eWeight:\u003c\/b\u003e 2.42lbs\u003cbr\u003e\u003cb\u003eSize:\u003c\/b\u003e 9.21h x 6.14w x 1.44d","brand":"Jie Xu","offers":[{"title":"Hardcover","offer_id":44920034525439,"sku":"9789811532658","price":219.99,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0662\/2982\/9887\/files\/img_5eb84b4c-5f94-44d5-bdb9-8830eeec270b.jpg?v=1710360027","url":"https:\/\/www.whiterainbookhouse.com\/products\/regulation-of-cancer-immune-checkpoints-jie-xu-9789811532658","provider":"WR Book House","version":"1.0","type":"link"}