{"product_id":"regulation-of-the-krzppel-like-factor-steven-yea-9783639103359","title":"Regulation of the Krüppel-like Factor 6 Tumor Suppressor","description":"KLF6 is a ubiquitously expressed Krüppel-like transcription factor whose role in vitro and in vivo role has not been fully identified. Like other members of the Krüppel-like family, KLF6 contains a conserved C-terminal three zinc finger DNA-binding domain (C2H2 motifs) and a unique N-terminal transactivation domain. KLF6 directly binds DNA at GC box promoter elements. Transcriptional targets of KLF6 include collagen 1, transforming growth factor beta 1 (TGFβ1), types I and II TGFβ receptors, urokinase type plasminogen activator (uPA), and the human immunodeficiency virus long terminal repeat (HIV-1 LTR). Here, we identify a novel mechanism of carcinogenesis, whereby oncogenic Ras signaling enhances alternative splicing-mediated inactivation of the KLF6 tumor suppressor in hepatocellular carcinomas. These Ras-dependent splice forms are shown to abrogate KLF6-mediated growth suppression, and ectopic KLF6 splice variant expression can restore a Ras-transformed phenotype.\u003cbr\u003e\u003cbr\u003e\u003cb\u003eAuthor:\u003c\/b\u003e Steven Yea,Scott L. Friedman\u003cbr\u003e\u003cb\u003eISBN-10:\u003c\/b\u003e 3639103351\u003cbr\u003e\u003cb\u003eISBN-13:\u003c\/b\u003e 9783639103359\u003cbr\u003e\u003cb\u003ePublisher:\u003c\/b\u003e VDM Verlag\u003cbr\u003e\u003cb\u003eLanguage:\u003c\/b\u003e English\u003cbr\u003e\u003cb\u003ePublished:\u003c\/b\u003e 11\/06\/2008\u003cbr\u003e\u003cb\u003ePages:\u003c\/b\u003e 168\u003cbr\u003e\u003cb\u003eFormat:\u003c\/b\u003e Paperback\u003cbr\u003e\u003cb\u003eWeight:\u003c\/b\u003e 0.51lbs\u003cbr\u003e\u003cb\u003eSize:\u003c\/b\u003e 9.00h x 6.00w x 0.36d","brand":"Steven Yea","offers":[{"title":"Paperback","offer_id":48113840914687,"sku":"9783639103359","price":73.44,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0662\/2982\/9887\/files\/img_6a70af50-3fc4-4d6c-8f36-abc7c27a0ed0.jpg?v=1769617520","url":"https:\/\/www.whiterainbookhouse.com\/products\/regulation-of-the-krzppel-like-factor-steven-yea-9783639103359","provider":"WR Book House","version":"1.0","type":"link"}