{"product_id":"resistance-of-cancer-cells-to-benjamin-bonavida-9783319178066","title":"Resistance of Cancer Cells to Ctl-Mediated Immunotherapy","description":"This comprehensive volume explores the latest research on the mechanisms of resistance in cancer cells to CTL-mediated immunotherapy. Chapter topics discuss cell-mediated immunity as the result of cytotoxic T-lymphocytes (CTL) directed specifically against cancer cells. In addition, the volume reviews how CTL mediate the cytotoxic activity, in large part, by the indication of apoptosis; hence, tumor cells develop anti-apoptotic mechanisms and thereby, resist CTL-induced apoptosis. In order for CTL-mediated antitumor immunotherapy to be effective, it is essential that agents directed against the resistant tumor cells sensitized cancer cells for CTL-mediated apoptosis. Examples of such agents discussed in the volume include are HDAC inhibitors, proteasome inhibitors, Bcl-2 family inhibitors, PARP, antibodies, and more.\u003cbr\u003e\u003cbr\u003e\u003cb\u003eAuthor:\u003c\/b\u003e Benjamin Bonavida\u003cbr\u003e\u003cb\u003eISBN-10:\u003c\/b\u003e 3319178067\u003cbr\u003e\u003cb\u003eISBN-13:\u003c\/b\u003e 9783319178066\u003cbr\u003e\u003cb\u003ePublisher:\u003c\/b\u003e Springer\u003cbr\u003e\u003cb\u003eLanguage:\u003c\/b\u003e English\u003cbr\u003e\u003cb\u003ePublished:\u003c\/b\u003e 06\/30\/2015\u003cbr\u003e\u003cb\u003ePages:\u003c\/b\u003e 353\u003cbr\u003e\u003cb\u003eFormat:\u003c\/b\u003e Hardcover\u003cbr\u003e\u003cb\u003eWeight:\u003c\/b\u003e 1.52lbs\u003cbr\u003e\u003cb\u003eSize:\u003c\/b\u003e 9.21h x 6.14w x 0.81d","brand":"Benjamin Bonavida","offers":[{"title":"Hardcover","offer_id":45331827753215,"sku":"9783319178066","price":109.99,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0662\/2982\/9887\/files\/img_26b8f7d8-87e4-4835-af17-404372f763ba.jpg?v=1713970999","url":"https:\/\/www.whiterainbookhouse.com\/products\/resistance-of-cancer-cells-to-benjamin-bonavida-9783319178066","provider":"WR Book House","version":"1.0","type":"link"}