{"product_id":"scope-and-limitations-of-the-constantin-rabong-9783639032819","title":"Scope and Limitations of the T-Reaction","description":"The quinoline motif is an integral part of a wide variety of bioactive classes of compounds. An increasingly popular entry into tetrahydroquinolines is represented by the T-reaction, i.e. a subtype of the transformations relying on the isomerization-cyclization sequence known as the tert.-amino-effect. The latter was shown to proceed via a most remarkable helical dipolar intermediate generated upon a hydrideshift from an alpha-amino-C-H in tert.-anilines to an unsaturated ortho-substituent, accomplishing C-C-bond formation from a nonactivated NCH-moiety. The tert.-amino-effect was first brought to the attention of the synthetic community in the seminal contribution of O. Meth-Cohn and H. Suschitzky from 1972. Since then, the protocol has progressively evolved into a convergent, economical and yield-efficient preparation of structurally diverse, highly functionalized and pharmacologically valuable heterocycles, bearing stereoselectively introduced centers of chirality.\u003cbr\u003e\u003cbr\u003e\u003cb\u003eAuthor:\u003c\/b\u003e Constantin Rabong\u003cbr\u003e\u003cb\u003eISBN-10:\u003c\/b\u003e 3639032810\u003cbr\u003e\u003cb\u003eISBN-13:\u003c\/b\u003e 9783639032819\u003cbr\u003e\u003cb\u003ePublisher:\u003c\/b\u003e VDM Verlag Dr. Mueller E.K.\u003cbr\u003e\u003cb\u003eLanguage:\u003c\/b\u003e English\u003cbr\u003e\u003cb\u003ePublished:\u003c\/b\u003e 05\/16\/2008\u003cbr\u003e\u003cb\u003ePages:\u003c\/b\u003e 204\u003cbr\u003e\u003cb\u003eFormat:\u003c\/b\u003e Paperback\u003cbr\u003e\u003cb\u003eWeight:\u003c\/b\u003e 0.62lbs\u003cbr\u003e\u003cb\u003eSize:\u003c\/b\u003e 9.00h x 6.00w x 0.43d","brand":"Constantin Rabong","offers":[{"title":"Paperback","offer_id":47305513468159,"sku":"9783639032819","price":85.32,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0662\/2982\/9887\/files\/img_f711aa73-f8e6-4c48-8849-96e18ddbfd50.jpg?v=1758831088","url":"https:\/\/www.whiterainbookhouse.com\/products\/scope-and-limitations-of-the-constantin-rabong-9783639032819","provider":"WR Book House","version":"1.0","type":"link"}