{"product_id":"statistical-methods-for-dose-finding-sylvie-chevret-9780470861233","title":"Statistical Methods for Dose-Finding","description":"\u003cp\u003eDose-finding experiments define the safe dosage of a drug in development, in terms of the quantity given to a patient. Statistical methods play a crucial role in identifying optimal dosage. Used appropriately, these methods provide reliable results and reduce trial duration and costs. In practice, however, dose-finding is often done poorly, with widely used conventional methods frequently being unreliable, leading to inaccurate results. However, there have been many advances in recent years, with new statistical techniques being developed and it is important that these new techniques are utilized correctly.\u003c\/p\u003e \u003cp\u003e\u003ci\u003eStatistical Methods for Dose-Finding Experiments\u003c\/i\u003e reviews the main statistical approaches for dose-finding in phase I\/II clinical trials and presents practical guidance on their correct use.\u003c\/p\u003e \u003cul\u003e \u003cli\u003eIncludes an introductory section, summarizing the essential concepts in dose-finding.\u003c\/li\u003e \u003cli\u003eContains a section on algorithm-based approaches, such as the traditional 3+3 design, and a section on model-based approaches, such as the continual reassessment method.\u003c\/li\u003e \u003cli\u003eExplains fundamental issues, such as how to stop trials early and how to cope with delayed or ordinal outcomes.\u003c\/li\u003e \u003cli\u003eDiscusses in detail the main websites and software used to implement the methods.\u003c\/li\u003e \u003cli\u003eFeatures numerous worked examples making use of real data.\u003c\/li\u003e \u003c\/ul\u003e \u003cp\u003e\u003ci\u003eStatistical Methods for Dose-Finding Experiments\u003c\/i\u003e is an important collaboration from the leading experts in the area. Primarily aimed at statisticians and clinicians working in clinical trials and medical research, there is also much to benefit graduate students of biostatistics.\u003c\/p\u003e\u003cbr\u003e\u003cbr\u003e\u003cb\u003eAuthor:\u003c\/b\u003e Sylvie Chevret\u003cbr\u003e\u003cb\u003eISBN-10:\u003c\/b\u003e 0470861231\u003cbr\u003e\u003cb\u003eISBN-13:\u003c\/b\u003e 9780470861233\u003cbr\u003e\u003cb\u003ePublisher:\u003c\/b\u003e Wiley\u003cbr\u003e\u003cb\u003eLanguage:\u003c\/b\u003e English\u003cbr\u003e\u003cb\u003ePublished:\u003c\/b\u003e 06\/01\/2006\u003cbr\u003e\u003cb\u003ePages:\u003c\/b\u003e 336\u003cbr\u003e\u003cb\u003eFormat:\u003c\/b\u003e Hardcover\u003cbr\u003e\u003cb\u003eWeight:\u003c\/b\u003e 1.31lbs\u003cbr\u003e\u003cb\u003eSize:\u003c\/b\u003e 9.15h x 6.45w x 0.92d","brand":"Sylvie Chevret","offers":[{"title":"Hardcover","offer_id":48013749453055,"sku":"9780470861233","price":123.95,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0662\/2982\/9887\/files\/img_d26dd561-aea1-46e6-8b71-d5c95f5e93cd.jpg?v=1767744528","url":"https:\/\/www.whiterainbookhouse.com\/products\/statistical-methods-for-dose-finding-sylvie-chevret-9780470861233","provider":"WR Book House","version":"1.0","type":"link"}