{"product_id":"stem-cell-dependent-therapies-gerhard-gross-9783110298260","title":"Stem Cell-Dependent Therapies: Mesenchymal Stem Cells in Chronic Inflammatory Disorders","description":"\u003cp\u003eMultipotent mesenchymal stem cells (MSCs) are a heterogeneous population of cells which reside in a variety of tissues. They differentiate into several mesodermal lineages, secrete a multitude of trophic factors and contribute to tissue homeostasis. MSCs are able to exert immunosuppressive activities by interfering with inflammatory cytokine production and with T- and B-cell proliferation. These immunomodulating properties make MSCs promising candidates for the treatment of chronic inflammatory and autoimmune disorders. There are, however, certain caveats involved including inappropriate migration of cells in the body, immune rejection, tumor formation, or graft versus host disease (GvHD). \u003cbr\u003eThis book investigates the current state of the MSC-dependent therapy of chronic inflammatory disorders and autoimmune diseases. Among the covered topics are GvHD, chronic kidney, liver and lung disease, ischemic heart and inflammatory bowel disease, diabetes, osteoarthritis, various rheumatic and neurological disorders and, lastly, tumors and solid organ transplantations. This book also questions the immunoprivileged status of MSCs, discusses the therapeutic role of MSCs in experimental animal disease models and their translation to the corresponding human disorders, envisions a role for MSCs in tumor interventions and, lastly, describes a systems biology approach for stem cells and inflammation. \u003cbr\u003e\u003c\/p\u003e\u003cbr\u003e\u003cbr\u003e\u003cb\u003eAuthor:\u003c\/b\u003e Gerhard Gross\u003cbr\u003e\u003cb\u003eISBN-10:\u003c\/b\u003e 3110298260\u003cbr\u003e\u003cb\u003eISBN-13:\u003c\/b\u003e 9783110298260\u003cbr\u003e\u003cb\u003ePublisher:\u003c\/b\u003e de Gruyter\u003cbr\u003e\u003cb\u003eLanguage:\u003c\/b\u003e English\u003cbr\u003e\u003cb\u003ePublished:\u003c\/b\u003e 10\/17\/2013\u003cbr\u003e\u003cb\u003ePages:\u003c\/b\u003e 426\u003cbr\u003e\u003cb\u003eFormat:\u003c\/b\u003e Hardcover\u003cbr\u003e\u003cb\u003eWeight:\u003c\/b\u003e 1.93lbs\u003cbr\u003e\u003cb\u003eSize:\u003c\/b\u003e 9.61h x 6.69w x 0.94d","brand":"Gerhard Gross","offers":[{"title":"Hardcover","offer_id":48113814864127,"sku":"9783110298260","price":340.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0662\/2982\/9887\/files\/img_08f48501-4b54-4edf-b8a5-9547cac2e9ce.jpg?v=1769617417","url":"https:\/\/www.whiterainbookhouse.com\/products\/stem-cell-dependent-therapies-gerhard-gross-9783110298260","provider":"WR Book House","version":"1.0","type":"link"}