{"product_id":"synthetic-cannabinoids-in-drug-discovery-florian-mohr-9783832551032","title":"Synthetic Cannabinoids in Drug Discovery: Design, Synthesis and Evaluation of Modified Coumarins as CB Receptor Ligands","description":"The endocannabinoid system represents a highly complex lipid-based (neuro-) transmitter system and can be found in nearly all animals. Since the discovery of the two main cannabinoid receptors CB1 and CB2 in the early '90, intensive research reviled a substantial influence of this system on many physiological and pathophysiological processes. Direct and selective targeting of the system bears a huge potential for the development of novel therapeutic approaches, especially for the treatment of chronical pain, inflammation or other neurological disorders. Therefore, the endocannabinoid system is a promising target in drug development. In the presented thesis, the design, syntheses and pharmacologic evaluation of substituted coumarins as potential new drug candidates as selective synthetic cannabinoids were investigated. In a combinatorial synthetic approach, several new libraries of new ligands were synthesised and subsequently pharmacological tested. Additionally, in a second project, novel reversible monoacylglycerol lipase (MAGL) inhibitors have been synthesized and pharmacologically evaluated. Thereby, several important structure-activity relationships for high potency or selectivity were found. Nearly all potencies of the developed inhibitors were determined in the nanomolar regions.\u003cbr\u003e\u003cbr\u003e\u003cb\u003eAuthor:\u003c\/b\u003e Florian Mohr\u003cbr\u003e\u003cb\u003eISBN-10:\u003c\/b\u003e 3832551034\u003cbr\u003e\u003cb\u003eISBN-13:\u003c\/b\u003e 9783832551032\u003cbr\u003e\u003cb\u003ePublisher:\u003c\/b\u003e Logos Verlag Berlin\u003cbr\u003e\u003cb\u003eLanguage:\u003c\/b\u003e English\u003cbr\u003e\u003cb\u003ePublished:\u003c\/b\u003e 05\/26\/2020\u003cbr\u003e\u003cb\u003ePages:\u003c\/b\u003e 354\u003cbr\u003e\u003cb\u003eFormat:\u003c\/b\u003e Paperback","brand":"Florian Mohr","offers":[{"title":"Paperback","offer_id":48450140995839,"sku":"9783832551032","price":79.0,"currency_code":"USD","in_stock":false}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0662\/2982\/9887\/files\/img_17a5a0ea-9ffb-4af3-aeb5-b54cb7e49db6.jpg?v=1777266389","url":"https:\/\/www.whiterainbookhouse.com\/products\/synthetic-cannabinoids-in-drug-discovery-florian-mohr-9783832551032","provider":"WR Book House","version":"1.0","type":"link"}