{"product_id":"systems-chemical-biology-slava-ziegler-9781493988907","title":"Systems Chemical Biology: Methods and Protocols","description":"\u003cp\u003e\u003c\/p\u003e\u003cp\u003eThis volume explores the latest available wet-lab techniques and computational methods to study in-cell small-molecule behavior and interactions with their targets. The chapters in this book discuss topics such as disease-relevant models for chemical biology studies, target engagement using cellular thermal shift assay or bioluminescence resonance energy transfer; visualization of bio-active small molecules Raman microscopy; (phospho-)proteomics and transcriptomics for mode-of-action studies, CRISPR\/Cas9-based chemogenomic profiling in mammalian cells; predicting drug interactions using computational approaches; comparison of compound-induced profiles using high-content imaging or cancer cell line panels and web-based tools for polypharmacology prediction. Written in the highly successful \u003ci\u003eMethods in Molecular Biology\u003c\/i\u003e series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. \u003c\/p\u003e\u003cp\u003e\u003c\/p\u003e Cutting-edge and thorough, \u003ci\u003eSystems Chemical Biology: Methods and Protocols \u003c\/i\u003eis a valuable resource for novice or expert scientists and researchers trying to initiate or continue their chemical biology studies at a systems level.\u003cp\u003e\u003c\/p\u003e\u003cbr\u003e\u003cbr\u003e\u003cb\u003eAuthor:\u003c\/b\u003e Slava Ziegler\u003cbr\u003e\u003cb\u003eISBN-10:\u003c\/b\u003e 1493988905\u003cbr\u003e\u003cb\u003eISBN-13:\u003c\/b\u003e 9781493988907\u003cbr\u003e\u003cb\u003ePublisher:\u003c\/b\u003e Humana\u003cbr\u003e\u003cb\u003eLanguage:\u003c\/b\u003e English\u003cbr\u003e\u003cb\u003ePublished:\u003c\/b\u003e 12\/06\/2018\u003cbr\u003e\u003cb\u003ePages:\u003c\/b\u003e 315\u003cbr\u003e\u003cb\u003eFormat:\u003c\/b\u003e Hardcover\u003cbr\u003e\u003cb\u003eWeight:\u003c\/b\u003e 1.73lbs\u003cbr\u003e\u003cb\u003eSize:\u003c\/b\u003e 10.00h x 7.00w x 0.75d","brand":"Slava Ziegler","offers":[{"title":"Hardcover","offer_id":48088402231551,"sku":"9781493988907","price":169.99,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0662\/2982\/9887\/files\/img_8ebc58fa-710a-4be1-b828-6339974f7cb0.jpg?v=1769104633","url":"https:\/\/www.whiterainbookhouse.com\/products\/systems-chemical-biology-slava-ziegler-9781493988907","provider":"WR Book House","version":"1.0","type":"link"}