{"product_id":"targeted-interference-with-signal-transduction-b-groner-9783540312086","title":"Targeted Interference with Signal Transduction Events","description":"\u003cp\u003eSequencing of the human genome and insights into signaling pathways have contributed to the understanding of cancer etiology and the development of new, improved cancer drugs. DNA mutations of a limited set of genes are responsible for the multiple stages of tumorigenesis and metastasis. Matching of therapeutic intervention with insights into the underlying molecular disease mechanism has led to the development of drugs such as Herceptin and Glivec. The deregulation of pathways due to mutated cancer genes provides the conceptual basis for future progress. Will it be possible to extrapolate this principle and derive more efficient drugs targeting cancer pathway components? Potential drug targets have been identified, but our ability to predict the consequences of inhibition of such components is still limited. The state of development of tomorrow's cancer drugs, directed against growth factors, growth factor receptors and intracellular signaling molecules with kinase activities, is described in this book.\u003c\/p\u003e\u003cbr\u003e\u003cbr\u003e\u003cb\u003eAuthor:\u003c\/b\u003e B. Groner\u003cbr\u003e\u003cb\u003eISBN-10:\u003c\/b\u003e 3540312080\u003cbr\u003e\u003cb\u003eISBN-13:\u003c\/b\u003e 9783540312086\u003cbr\u003e\u003cb\u003ePublisher:\u003c\/b\u003e Springer\u003cbr\u003e\u003cb\u003eLanguage:\u003c\/b\u003e English\u003cbr\u003e\u003cb\u003ePublished:\u003c\/b\u003e 06\/05\/2007\u003cbr\u003e\u003cb\u003ePages:\u003c\/b\u003e 188\u003cbr\u003e\u003cb\u003eFormat:\u003c\/b\u003e Hardcover\u003cbr\u003e\u003cb\u003eWeight:\u003c\/b\u003e 1.15lbs\u003cbr\u003e\u003cb\u003eSize:\u003c\/b\u003e 9.61h x 6.69w x 0.50d","brand":"B. Groner","offers":[{"title":"Hardcover","offer_id":48486948208895,"sku":"9783540312086","price":109.99,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0662\/2982\/9887\/files\/img_fa5eabdc-78ab-4cfd-aec3-8f0b3fc759c3.jpg?v=1778057330","url":"https:\/\/www.whiterainbookhouse.com\/products\/targeted-interference-with-signal-transduction-b-groner-9783540312086","provider":"WR Book House","version":"1.0","type":"link"}