{"product_id":"targeting-cytoplasmic-tyrosine-kinases-in-ahmed-abd-el-kader-9786138392491","title":"Targeting Cytoplasmic Tyrosine Kinases in Cancer","description":"Protein kinases are critical regulators of cell signaling and represent one of the most successful classes of drug targets in oncology. Among them, cytoplasmic tyrosine kinases (CTKs) play a pivotal role in controlling cell growth, survival, and differentiation. This review provides a comprehensive overview of CTKs as therapeutic targets, with a particular focus on the c-Abl kinase and its oncogenic counterpart, Bcr-Abl, in Chronic Myeloid Leukemia (CML). A significant portion of the review is dedicated to the development and clinical evolution of Bcr-Abl inhibitors, from first-generation ATP-competitive drugs like imatinib to second- and third-generation agents designed to overcome resistance. Finally, we discuss the clinical landscape of kinase inhibitors and future perspectives, positioning the Bcr-Abl story as a paradigm for targeted cancer therapy.\u003cbr\u003e\u003cbr\u003e\u003cb\u003eAuthor:\u003c\/b\u003e Ahmed Abd El-Kader\u003cbr\u003e\u003cb\u003eISBN-10:\u003c\/b\u003e 6138392493\u003cbr\u003e\u003cb\u003eISBN-13:\u003c\/b\u003e 9786138392491\u003cbr\u003e\u003cb\u003ePublisher:\u003c\/b\u003e Noor Publishing\u003cbr\u003e\u003cb\u003eLanguage:\u003c\/b\u003e English\u003cbr\u003e\u003cb\u003ePublished:\u003c\/b\u003e 10\/06\/2025\u003cbr\u003e\u003cb\u003ePages:\u003c\/b\u003e 56\u003cbr\u003e\u003cb\u003eFormat:\u003c\/b\u003e Paperback\u003cbr\u003e\u003cb\u003eWeight:\u003c\/b\u003e 0.19lbs\u003cbr\u003e\u003cb\u003eSize:\u003c\/b\u003e 9.00h x 6.00w x 0.13d","brand":"Ahmed Abd El-Kader","offers":[{"title":"Paperback","offer_id":48437563916543,"sku":"9786138392491","price":29.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0662\/2982\/9887\/files\/img_61647d00-39e7-4fb5-b049-7dcb34aa429a.jpg?v=1777162654","url":"https:\/\/www.whiterainbookhouse.com\/products\/targeting-cytoplasmic-tyrosine-kinases-in-ahmed-abd-el-kader-9786138392491","provider":"WR Book House","version":"1.0","type":"link"}