{"product_id":"telomeres-carole-saintome-9781789450972","title":"Telomeres: Chromosome Sentinels","description":"\u003cp\u003eTelomeres are specialized DNA-protein structures that protect the ends of chromosomes to maintain their integrity. They are chromosome sentinels. This book, written by multiple authors, presents current knowledge and the most recent discoveries relating to telomeres.\u003c\/p\u003e \u003cp\u003eThe first chapters describe telomere structures (DNA and proteins), organization, dynamics and replication in a range of organisms including ciliates, yeast and mammals. The following chapters cover mechanisms that maintain telomere length involving telomerase and Alternative Lengthening Telomeres (ALT) mechanisms. Interestingly, telomeres are transcribed into repetitive RNA called TERRA (Telomeric repeat-containing RNA), the state of the art regarding mammalian telomere transcripts is presented here.\u003c\/p\u003e \u003cp\u003eTwo chapters are dedicated to the description of how telomere biology impacts the development of cancer and how their disfunctions induce telomeropathies (telomere biology disorders). Finally, the book ends with a chapter presenting telomere and telomerase targeting agents as potential anticancer agents, a promising therapeutic approach.\u003c\/p\u003e\u003cbr\u003e\u003cbr\u003e\u003cb\u003eAuthor:\u003c\/b\u003e Carole Saintome\u003cbr\u003e\u003cb\u003eISBN-10:\u003c\/b\u003e 1789450977\u003cbr\u003e\u003cb\u003eISBN-13:\u003c\/b\u003e 9781789450972\u003cbr\u003e\u003cb\u003ePublisher:\u003c\/b\u003e Wiley-Iste\u003cbr\u003e\u003cb\u003eLanguage:\u003c\/b\u003e English\u003cbr\u003e\u003cb\u003ePublished:\u003c\/b\u003e 07\/23\/2024\u003cbr\u003e\u003cb\u003ePages:\u003c\/b\u003e 400\u003cbr\u003e\u003cb\u003eFormat:\u003c\/b\u003e Hardcover\u003cbr\u003e\u003cb\u003eWeight:\u003c\/b\u003e 1.61lbs\u003cbr\u003e\u003cb\u003eSize:\u003c\/b\u003e 9.21h x 6.14w x 0.88d","brand":"Carole Saintome","offers":[{"title":"Hardcover","offer_id":46311205699839,"sku":"9781789450972","price":165.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0662\/2982\/9887\/files\/img_40bb5a0e-cb6f-45c9-9c73-c93121b91f81.jpg?v=1730888836","url":"https:\/\/www.whiterainbookhouse.com\/products\/telomeres-carole-saintome-9781789450972","provider":"WR Book House","version":"1.0","type":"link"}