{"product_id":"the-biology-of-the-tgf-rik-derynck-9781621820369","title":"The Biology of the Tgf-ﾟ Family","description":"The transforming growth factor (TGF-) family is a large group of structurally related proteins that drive developmental programs and control cell behavior. The TGF- family members exert their effects by binding to receptors on the cell surface, activating intracellular signaling pathways that modulate gene expression programs that control normal cell physiology, immune responses, and a variety of developmental processes. TGF- signaling is also important in conditions such as cancer, skeletal disorders, and cardiovascular diseases. \u003cp\u003e\u003c\/p\u003eWritten and edited by experts in the field, this collection from \u003cem\u003eCold Spring Harbor Perspectives in Biology\u003c\/em\u003e provides a comprehensive view of the different members of the TGF- family, the signaling pathways they control, and how they influence development, normal physiology, and disease. The contributors describe the various TGF- family ligands, including activins and bone morphogenetic proteins (BMPs), the structures and functions of the type I and type II receptors, and how ligand-receptor binding is regulated. Both Smad and non-Smad signaling pathways are discussed, as is cross talk between TGF- and other signaling pathways (e.g., Wnt). Individual chapters are devoted to the roles of TGF- signaling in specific biological processes, including cell proliferation, mesenchymal differentiation, branching morphogenesis, stem cell biology, immunity, vascular function, reproduction, and neurobiology. The roles of TGF- signaling in cancer, fibrosis, skeletal diseases, and other conditions, as well as prospects for therapeutics, are also covered. \u003cp\u003e\u003c\/p\u003eThe authors also review TGF- signaling in model organisms (e.g., C. elegans and Drosophila), as well as the discovery of TGF- and early research in the field. This volume is therefore a comprehensive reference on the biology of the TGF- family, and it will be valuable for not only cell and developmental biologists but all who wish to learn about this important field of research.\u003cbr\u003e\u003cbr\u003e\u003cbr\u003e\u003cb\u003eAuthor:\u003c\/b\u003e Rik Derynck\u003cbr\u003e\u003cb\u003eISBN-10:\u003c\/b\u003e 162182036X\u003cbr\u003e\u003cb\u003eISBN-13:\u003c\/b\u003e 9781621820369\u003cbr\u003e\u003cb\u003ePublisher:\u003c\/b\u003e Cold Spring Harbor Laboratory Press\u003cbr\u003e\u003cb\u003eLanguage:\u003c\/b\u003e English\u003cbr\u003e\u003cb\u003ePublished:\u003c\/b\u003e 04\/30\/2017\u003cbr\u003e\u003cb\u003ePages:\u003c\/b\u003e 400\u003cbr\u003e\u003cb\u003eFormat:\u003c\/b\u003e Hardcover\u003cbr\u003e\u003cb\u003eWeight:\u003c\/b\u003e 6.00lbs\u003cbr\u003e\u003cb\u003eSize:\u003c\/b\u003e 10.20h x 7.40w x 2.00d","brand":"Rik Derynck","offers":[{"title":"Hardcover","offer_id":44966360088831,"sku":"9781621820369","price":33.75,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0662\/2982\/9887\/files\/img_b829b8a5-efeb-4d75-bf74-cd926dbfda3a.jpg?v=1711159626","url":"https:\/\/www.whiterainbookhouse.com\/products\/the-biology-of-the-tgf-rik-derynck-9781621820369","provider":"WR Book House","version":"1.0","type":"link"}