{"product_id":"the-human-t-cell-receptor-repertoire-peter-van-den-elsen-9783662224960","title":"The Human T-Cell Receptor Repertoire and Transplantation","description":"these analyses it became clear that the MHC class I molecule com- prised a distinct groove on the external side of the molecule. The sides of the groove are formed by the a-helical structures of the a and a 1 2 domains and a floor which is formed by 8 anti-parallel 13 strands. The various polymorphic residues, as determined from DNA sequence analysis, are localized within these a-helices and 13-plated sheets within the groove. More importantly, these analyses also revealed the presence of elec- tron-dense material in the groove. This material was subsequently iden- 568 10 tified as a linear peptide of 8-10 amino acids long. - -- High resolu- tion crystallographic analyses of the class I MHC structure have revealed the existence of so-called pockets within the grooves of the MHC class I molecules. These pockets designated A-F, exhibited allele-specificity and are directly involved in the binding of the peptide, primarily through interaction with the dominant anchor residues as found in MHC class I associated pep tides. 6,7,9,11 The class II MHC antigens consist on the cell surface of a 34 kD a chain non-covalently associated with a 28 kD 13 chain. With the excep- tion of the DR a-chain, all other MHC class II a and 13 chains are poly- morphic.\u003cbr\u003e\u003cbr\u003e\u003cb\u003eAuthor:\u003c\/b\u003e Peter Van Den Elsen\u003cbr\u003e\u003cb\u003eISBN-10:\u003c\/b\u003e 3662224968\u003cbr\u003e\u003cb\u003eISBN-13:\u003c\/b\u003e 9783662224960\u003cbr\u003e\u003cb\u003ePublisher:\u003c\/b\u003e Springer\u003cbr\u003e\u003cb\u003eLanguage:\u003c\/b\u003e English\u003cbr\u003e\u003cb\u003ePublished:\u003c\/b\u003e 11\/13\/2013\u003cbr\u003e\u003cb\u003ePages:\u003c\/b\u003e 173\u003cbr\u003e\u003cb\u003eFormat:\u003c\/b\u003e Paperback\u003cbr\u003e\u003cb\u003eWeight:\u003c\/b\u003e 0.74lbs\u003cbr\u003e\u003cb\u003eSize:\u003c\/b\u003e 10.00h x 7.00w x 0.40d","brand":"Peter Van Den Elsen","offers":[{"title":"Paperback","offer_id":47930949894399,"sku":"9783662224960","price":109.99,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0662\/2982\/9887\/files\/img_3f8eef50-7fa7-4459-9e01-eb33c7b6890f.jpg?v=1766345411","url":"https:\/\/www.whiterainbookhouse.com\/products\/the-human-t-cell-receptor-repertoire-peter-van-den-elsen-9783662224960","provider":"WR Book House","version":"1.0","type":"link"}