{"product_id":"the-molecular-switch-rob-phillips-9780691200248","title":"The Molecular Switch: Signaling and Allostery","description":"\u003cp\u003eA signature feature of living organisms is their ability to carry out purposeful actions by taking stock of the world around them. To that end, cells have an arsenal of signaling molecules linked together in signaling pathways, which switch between inactive and active conformations. \u003ci\u003eThe Molecular Switch\u003c\/i\u003e articulates a biophysical perspective on signaling, showing how allostery--a powerful explanation of how molecules function across all biological domains--can be reformulated using equilibrium statistical mechanics, applied to diverse biological systems exhibiting switching behaviors, and successfully unify seemingly unrelated phenomena. \u003c\/p\u003e\u003cp\u003e\u003c\/p\u003eRob Phillips weaves together allostery and statistical mechanics via a series of biological vignettes, each of which showcases an important biological question and accompanying physical analysis. Beginning with the study of ligand-gated ion channels and their role in problems ranging from muscle action to vision, Phillips then undertakes increasingly sophisticated case studies, from bacterial chemotaxis and quorum sensing to hemoglobin and its role in mammalian physiology. He looks at G-protein coupled receptors as well as the role of allosteric molecules in gene regulation. Phillips concludes by surveying problems in biological fidelity and offering a speculative chapter on the relationship between allostery and biological Maxwell demons. \u003cp\u003e\u003c\/p\u003eAppropriate for graduate students and researchers in biophysics, physics, engineering, biology, and neuroscience, \u003ci\u003eThe Molecular Switch\u003c\/i\u003e presents a unified, quantitative model for describing biological signaling phenomena.\u003cbr\u003e\u003cbr\u003e\u003cb\u003eAuthor:\u003c\/b\u003e Rob Phillips\u003cbr\u003e\u003cb\u003eISBN-10:\u003c\/b\u003e 0691200246\u003cbr\u003e\u003cb\u003eISBN-13:\u003c\/b\u003e 9780691200248\u003cbr\u003e\u003cb\u003ePublisher:\u003c\/b\u003e Princeton University Press\u003cbr\u003e\u003cb\u003eLanguage:\u003c\/b\u003e English\u003cbr\u003e\u003cb\u003ePublished:\u003c\/b\u003e 09\/01\/2020\u003cbr\u003e\u003cb\u003ePages:\u003c\/b\u003e 440\u003cbr\u003e\u003cb\u003eFormat:\u003c\/b\u003e Hardcover\u003cbr\u003e\u003cb\u003eWeight:\u003c\/b\u003e 3.75lbs\u003cbr\u003e\u003cb\u003eSize:\u003c\/b\u003e 10.00h x 8.00w x 1.10d","brand":"Rob Phillips","offers":[{"title":"Hardcover","offer_id":43978316447999,"sku":"9780691200248","price":99.95,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0662\/2982\/9887\/files\/img_1f51809e-cdaa-4a9e-886d-b366c2fb7d78.jpg?v=1683240868","url":"https:\/\/www.whiterainbookhouse.com\/products\/the-molecular-switch-rob-phillips-9780691200248","provider":"WR Book House","version":"1.0","type":"link"}