{"product_id":"the-prion-protein-jorg-tatzelt-9781912530076","title":"The Prion Protein","description":"\u003cp\u003eA conformational transition of the cellular prion protein (PrP\u003csup\u003eC\u003c\/sup\u003e) into an aberrantly folded isoform designated scrapie prion protein (PrP\u003csup\u003eSc\u003c\/sup\u003e) is the hallmark of a variety of neurodegenerative disorders collectively called prion diseases. They include Creutzfeldt-Jakob disease and Gerstmann-Stäussler-Scheinker syndrome in humans, scrapie in sheep, bovine spongiform encephalopathy (BSE) in cattle and chronic wasting disease (CWD) in free-ranging deer. In contrast to the deadly properties of misfolded PrP, PrP\u003csup\u003eC\u003c\/sup\u003e seems to possess a neuroprotective activity. More-over, animal models indicated that the stress-protective activity of PrP\u003csup\u003eC\u003c\/sup\u003e and the neurotoxic effects of PrP\u003csup\u003eSc\u003c\/sup\u003e are somehow interconnected. In this timely book, leading scientists in the field have come together to highlight the apparently incongruous activities of different PrP conformers. The articles outline current research on celluar pathways implicated in the formation and signaling of neurotoxic and physiological PrP isoforms and delineate future research direction. Topics covered include the physiologcial activity of PrP\u003csup\u003eC\u003c\/sup\u003e and its possible role as a neurotrophic factor, the finding that aberrant PrP conformers can cause neurodegeneration in the absence of infectious prion propagation, the requirement of the GPI anchor of PrP\u003csup\u003eC\u003c\/sup\u003e for the neurotoxic effects of scrapie prions, the pathways implicated in the formation and neurotoxic properties of cytosolically localized PrP, the impact of metal ions on the processing of PrP, and the role of autophagy in the propagation and clearance of PrP\u003csup\u003eSc\u003c\/sup\u003e. The book is fully illustrated and chapters include comprehensive reference sections. Essential reading for scientists involved in prion research.\u003c\/p\u003e\u003cbr\u003e\u003cbr\u003e\u003cb\u003eAuthor:\u003c\/b\u003e Jorg Tatzelt\u003cbr\u003e\u003cb\u003eISBN-10:\u003c\/b\u003e 1912530074\u003cbr\u003e\u003cb\u003eISBN-13:\u003c\/b\u003e 9781912530076\u003cbr\u003e\u003cb\u003ePublisher:\u003c\/b\u003e Caister Academic Press Limited\u003cbr\u003e\u003cb\u003eLanguage:\u003c\/b\u003e English\u003cbr\u003e\u003cb\u003ePublished:\u003c\/b\u003e 01\/01\/2010\u003cbr\u003e\u003cb\u003ePages:\u003c\/b\u003e 86\u003cbr\u003e\u003cb\u003eFormat:\u003c\/b\u003e Paperback\u003cbr\u003e\u003cb\u003eWeight:\u003c\/b\u003e 0.28lbs\u003cbr\u003e\u003cb\u003eSize:\u003c\/b\u003e 9.00h x 6.00w x 0.18d","brand":"Jorg Tatzelt","offers":[{"title":"Paperback","offer_id":48065975746815,"sku":"9781912530076","price":250.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0662\/2982\/9887\/files\/img_8b88755a-776a-472c-8610-7e10786806a1.jpg?v=1768677808","url":"https:\/\/www.whiterainbookhouse.com\/products\/the-prion-protein-jorg-tatzelt-9781912530076","provider":"WR Book House","version":"1.0","type":"link"}