{"product_id":"the-role-of-microenvironment-in-domenico-ribatti-9783319278186","title":"The Role of Microenvironment in the Control of Tumor Angiogenesis","description":"\u003cp\u003eThis work describes the importance of tumor microenvironment in favouring tumor progression and angiogenesis.\u003c\/p\u003e\u003cp\u003eUnder physiological conditions, angiogenesis is dependent on the balance of positive and negative angiogenic modulators within the vascular microenvironment and requires the functional activities of a number of molecules, including angiogenic factors, extracellular matrix proteins, adhesion molecules and proteolytic enzymes.\u003cbr\u003e\u003c\/p\u003e\u003cp\u003e\u003c\/p\u003e\u003cp\u003eIn normal tissues, vascular quiescence is maintained by the dominant influence of endogenous angiogenesis inhibitors over angiogenic stimuli.\u003c\/p\u003e\u003cp\u003e\u003c\/p\u003e\u003cp\u003eTumor angiogenesis is linked to a switch in the balance between positive and negative regulators, and mainly depends on the release by inflammatory or neoplastic cells of specific growth factors for endothelial cells, that stimulate the growth of the blood vessels of the host or the down-regulation of natural angiogenesis inhibitors.\u003cbr\u003e\u003c\/p\u003e\u003cp\u003e\u003c\/p\u003e\u003cp\u003eIn particular, the inflammatory infiltrate may contribute to tumor angiogenesis, and there are many reports of associations between tumor inflammatory infiltrate, vascularity and prognosis.\u003c\/p\u003e\u003cp\u003eNew therapeutic approaches have been developed with the aim to control tumor angiogenesis through targeting of different components of tumor microenvironment. \u003c\/p\u003e\u003cp\u003e\u003cbr\u003e\u003c\/p\u003e\u003cbr\u003e\u003cbr\u003e\u003cb\u003eAuthor:\u003c\/b\u003e Domenico Ribatti\u003cbr\u003e\u003cb\u003eISBN-10:\u003c\/b\u003e 3319278185\u003cbr\u003e\u003cb\u003eISBN-13:\u003c\/b\u003e 9783319278186\u003cbr\u003e\u003cb\u003ePublisher:\u003c\/b\u003e Springer\u003cbr\u003e\u003cb\u003eLanguage:\u003c\/b\u003e English\u003cbr\u003e\u003cb\u003ePublished:\u003c\/b\u003e 02\/16\/2016\u003cbr\u003e\u003cb\u003ePages:\u003c\/b\u003e 86\u003cbr\u003e\u003cb\u003eFormat:\u003c\/b\u003e Hardcover\u003cbr\u003e\u003cb\u003eWeight:\u003c\/b\u003e 0.71lbs\u003cbr\u003e\u003cb\u003eSize:\u003c\/b\u003e 9.21h x 6.14w x 0.31d","brand":"Domenico Ribatti","offers":[{"title":"Hardcover","offer_id":46907095187711,"sku":"9783319278186","price":109.99,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0662\/2982\/9887\/files\/img_acaa4ca8-fff6-4f23-a4c6-8865f4f0cc4f.jpg?v=1748772303","url":"https:\/\/www.whiterainbookhouse.com\/products\/the-role-of-microenvironment-in-domenico-ribatti-9783319278186","provider":"WR Book House","version":"1.0","type":"link"}