{"product_id":"the-role-of-toll-like-receptor-carlo-rossetti-9783030563189","title":"The Role of Toll-Like Receptor 4 in Infectious and Non Infectious Inflammation","description":"\u003cp\u003eTLR4 is one of the most important innate immunity receptors, its function mainly consisting in the activation of inflammatory pathways in response to stimulation by Pathogen-Associated Molecular Patterns (PAMPs) and Damage Associated Molecular Pattern molecules (DAMPs).\u003cbr\u003e\u003c\/p\u003e \u003cp\u003eThis volume critically reviews the different types of TLR4 activators and inhibitors, discusses the role of molecular aggregates in agonism\/antagonism as well as the pivotal role of the CD14 receptor in the modulation of TLR4 signal and the molecular details and actors of the intracellular cascade.\u003c\/p\u003e \u003cp\u003eThe book presents the role of TLR4 in several pathologies, such as sepsis and septic shock caused by receptor activation by gram-negative bacterial lipopolysaccharide (LPS), in neurodegenerative and neurological diseases such as Parkinson and Alzheimer's diseases, and Amyotrophic Lateral Sclerosis (ALS). It reviews the role of TLR4 in neural stem cell-mediated neurogenesis and neuroinflammation and in Human Induced Pluripotent Stem Cells and Cerebral Organoids and discusses the emerging role of micro-RNA (miRNA) regulation by TLR4. \u003c\/p\u003e \u003cp\u003e\u003cbr\u003e\u003c\/p\u003e \u003cp\u003e\u003cbr\u003e\u003c\/p\u003e\u003cp\u003e\u003cbr\u003e\u003c\/p\u003e\u003cbr\u003e\u003cbr\u003e\u003cb\u003eAuthor:\u003c\/b\u003e Carlo Rossetti\u003cbr\u003e\u003cb\u003eISBN-10:\u003c\/b\u003e 3030563189\u003cbr\u003e\u003cb\u003eISBN-13:\u003c\/b\u003e 9783030563189\u003cbr\u003e\u003cb\u003ePublisher:\u003c\/b\u003e Springer\u003cbr\u003e\u003cb\u003eLanguage:\u003c\/b\u003e English\u003cbr\u003e\u003cb\u003ePublished:\u003c\/b\u003e 10\/31\/2020\u003cbr\u003e\u003cb\u003ePages:\u003c\/b\u003e 174\u003cbr\u003e\u003cb\u003eFormat:\u003c\/b\u003e Hardcover\u003cbr\u003e\u003cb\u003eWeight:\u003c\/b\u003e 0.97lbs\u003cbr\u003e\u003cb\u003eSize:\u003c\/b\u003e 9.21h x 6.14w x 0.50d","brand":"Carlo Rossetti","offers":[{"title":"Hardcover","offer_id":44169952395519,"sku":"9783030563189","price":109.99,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0662\/2982\/9887\/files\/img_c9953f46-796e-46db-b521-7a15e13df1b6.jpg?v=1689655945","url":"https:\/\/www.whiterainbookhouse.com\/products\/the-role-of-toll-like-receptor-carlo-rossetti-9783030563189","provider":"WR Book House","version":"1.0","type":"link"}