{"product_id":"the-synapse-virginia-m-pickel-9780124186750","title":"The Synapse: Structure and Function","description":"\u003cp\u003e\u003ci\u003eThe Synapse\u003c\/i\u003e summarizes recent advances in cellular and molecular mechanisms of synaptic transmission and provides new insights into neuronal plasticity and the cellular basis of neurological diseases. \u003c\/p\u003e \u003cul\u003e \u003cli\u003ePart 1 provides an in-depth look at structural differences and distribution of various pre- and post-synaptic proteins found at glutamatergic synapses.\u003c\/li\u003e \u003cli\u003ePart 2 is dedicated to dendritic spines and their associated perisynaptic glia, which together constitute the tripartite synapse. The spines are portrayed as major sites for calcium sequestration and local protein synthesis.\u003c\/li\u003e \u003cli\u003ePart 3 highlights the important regional and cellular differences between glutamatergic transmission and that of neurotransmitters such as dopamine and acetylcholine that are commonly found in axon terminals without synaptic membrane specializations.\u003c\/li\u003e \u003cli\u003ePart 4 provides an overview of the synapse from the time of formation to degeneration under the powerful influence of aging or hormonal decline that leads to severe deficits in cognitive function.\u003c\/li\u003e\n\u003c\/ul\u003e \u003cp\u003eEach chapter is illustrated with drawings and images derived from calcium imaging, electron microscopic immunolabeling, or electrophysiology. This book is a valuable reference for neuroscientists and clinical neurologists in both research and clinical settings.\u003c\/p\u003e\u003cbr\u003e\u003cbr\u003e\u003cb\u003eAuthor:\u003c\/b\u003e Virginia M. Pickel\u003cbr\u003e\u003cb\u003eISBN-10:\u003c\/b\u003e 0124186750\u003cbr\u003e\u003cb\u003eISBN-13:\u003c\/b\u003e 9780124186750\u003cbr\u003e\u003cb\u003ePublisher:\u003c\/b\u003e Academic Press\u003cbr\u003e\u003cb\u003eLanguage:\u003c\/b\u003e English\u003cbr\u003e\u003cb\u003ePublished:\u003c\/b\u003e 12\/10\/2013\u003cbr\u003e\u003cb\u003ePages:\u003c\/b\u003e 512\u003cbr\u003e\u003cb\u003eFormat:\u003c\/b\u003e Hardcover\u003cbr\u003e\u003cb\u003eWeight:\u003c\/b\u003e 2.90lbs\u003cbr\u003e\u003cb\u003eSize:\u003c\/b\u003e 9.40h x 7.50w x 1.10d","brand":"Virginia M. Pickel","offers":[{"title":"Hardcover","offer_id":48112832479487,"sku":"9780124186750","price":175.0,"currency_code":"USD","in_stock":false}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0662\/2982\/9887\/files\/img_f9e8a145-81b4-45b0-b4cc-b47bb59370d1.jpg?v=1769611241","url":"https:\/\/www.whiterainbookhouse.com\/products\/the-synapse-virginia-m-pickel-9780124186750","provider":"WR Book House","version":"1.0","type":"link"}