{"product_id":"therapeutic-peptides-andrew-e-nixon-9781627036726","title":"Therapeutic Peptides: Methods and Protocols","description":"\u003cp\u003eIn this volume we will cover technologies and associated methodologies that allow identification, characterization and application of therapeutic peptides.\u003c\/p\u003e \u003cp\u003e\u003c\/p\u003e \u003cp\u003eThe section covering identification will cover areas such as display on the surface of filamentous or lytic phage, substrate phage display, ribosome display and the use of peptide library pools. \u003c\/p\u003e \u003cp\u003e\u003c\/p\u003e \u003cp\u003eOften the output from library selection is not a peptide but the sequence of a peptide. We will therefore discuss approaches to produce peptide ligands both synthetically and through recombinant techniques. This section will also include a discussion of how peptides may be produced such that their serum residence time can be extended to allow weekly dosing such as fusions to other larger proteins or through modification with PEG.\u003c\/p\u003e \u003cp\u003e\u003c\/p\u003e \u003cp\u003eThe next section covers biophysical tools for characterization of peptide interactions with proteins. These include fluorescence polarization, equilibrium dialysis, radioligand binding assays, regular and array based SPR analysis.\u003c\/p\u003e \u003cp\u003e\u003c\/p\u003e \u003cp\u003eThe remaining section outlines methods for preparation and application of peptides as: imaging agents; targeting agents for radionuclei; receptor antagonists, and as tools to mediate cell penetration\u003c\/p\u003e\u003cbr\u003e\u003cbr\u003e\u003cb\u003eAuthor:\u003c\/b\u003e Andrew E. Nixon\u003cbr\u003e\u003cb\u003eISBN-10:\u003c\/b\u003e 1627036725\u003cbr\u003e\u003cb\u003eISBN-13:\u003c\/b\u003e 9781627036726\u003cbr\u003e\u003cb\u003ePublisher:\u003c\/b\u003e Humana\u003cbr\u003e\u003cb\u003eLanguage:\u003c\/b\u003e English\u003cbr\u003e\u003cb\u003ePublished:\u003c\/b\u003e 10\/22\/2013\u003cbr\u003e\u003cb\u003ePages:\u003c\/b\u003e 279\u003cbr\u003e\u003cb\u003eFormat:\u003c\/b\u003e Hardcover\u003cbr\u003e\u003cb\u003eWeight:\u003c\/b\u003e 1.50lbs\u003cbr\u003e\u003cb\u003eSize:\u003c\/b\u003e 10.10h x 7.20w x 0.80d","brand":"Andrew E. Nixon","offers":[{"title":"Hardcover","offer_id":44125087498495,"sku":"9781627036726","price":119.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0662\/2982\/9887\/files\/img_59852b4d-975f-4d49-8946-1a1c79b78cec.jpg?v=1687440569","url":"https:\/\/www.whiterainbookhouse.com\/products\/therapeutic-peptides-andrew-e-nixon-9781627036726","provider":"WR Book House","version":"1.0","type":"link"}