{"product_id":"topics-on-drug-metabolism-james-paxton-9789535100997","title":"Topics on Drug Metabolism","description":"In order to avoid late-stage drug failure due to factors such as undesirable metabolic instability, toxic metabolites, drug-drug interactions, and polymorphic metabolism, an enormous amount of effort has been expended by both the pharmaceutical industry and academia towards developing more powerful techniques and screening assays to identify the metabolic profiles and enzymes involved in drug metabolism. This book presents some in-depth reviews of selected topics in drug metabolism. Among the key topics covered are: the interplay between drug transport and metabolism in oral bioavailability; the influence of genetic and epigenetic factors on drug metabolism; impact of disease on transport and metabolism; and the use of novel microdosing techniques and novel LC\/MS and genomic technologies to predict the metabolic parameters and profiles of potential new drug candidates.\u003cbr\u003e\u003cbr\u003e\u003cb\u003eAuthor:\u003c\/b\u003e James Paxton\u003cbr\u003e\u003cb\u003eISBN-10:\u003c\/b\u003e 9535100998\u003cbr\u003e\u003cb\u003eISBN-13:\u003c\/b\u003e 9789535100997\u003cbr\u003e\u003cb\u003ePublisher:\u003c\/b\u003e Intechopen\u003cbr\u003e\u003cb\u003eLanguage:\u003c\/b\u003e English\u003cbr\u003e\u003cb\u003ePublished:\u003c\/b\u003e 02\/22\/2012\u003cbr\u003e\u003cb\u003ePages:\u003c\/b\u003e 310\u003cbr\u003e\u003cb\u003eFormat:\u003c\/b\u003e Hardcover\u003cbr\u003e\u003cb\u003eWeight:\u003c\/b\u003e 1.53lbs\u003cbr\u003e\u003cb\u003eSize:\u003c\/b\u003e 9.61h x 6.69w x 0.75d","brand":"James Paxton","offers":[{"title":"Hardcover","offer_id":48089172050175,"sku":"9789535100997","price":179.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0662\/2982\/9887\/files\/img_a8984ee6-5448-49a8-b7a1-c352e388f7f6.jpg?v=1769108603","url":"https:\/\/www.whiterainbookhouse.com\/products\/topics-on-drug-metabolism-james-paxton-9789535100997","provider":"WR Book House","version":"1.0","type":"link"}