{"product_id":"total-synthesis-of-natural-products-andrew-giltrap-9789811088056","title":"Total Synthesis of Natural Products with Antimicrobial Activity","description":"This thesis focuses on the development of efficient and scalable total syntheses of natural products that can be used as preferred scaffolds for anti-infective drug discovery. It describes the total synthesis of two classes of antimicrobial non-ribosomal peptides (NRPs) - teixobactin and the skyllamycins - with subsequent biological evaluation. The first part describes the first total synthesis of teixobactin by means of a solid-phase peptide synthesis-macrolactamisation approach, yielding a synthetic natural product that can combat a number of clinically relevant Gram-positive bacterial pathogens. The second part describes the first total synthesis of skyllamycins A-C, a family of structurally complex cyclic NRPs, which inhibit the growth of the \u003ci\u003ePseudomonas aeruginosa\u003c\/i\u003e biofilms that are responsible for significant mortality among cystic fibrosis patients.\u003cbr\u003e\u003cbr\u003e\u003cbr\u003e\u003cb\u003eAuthor:\u003c\/b\u003e Andrew Giltrap\u003cbr\u003e\u003cb\u003eISBN-10:\u003c\/b\u003e 9811088055\u003cbr\u003e\u003cb\u003eISBN-13:\u003c\/b\u003e 9789811088056\u003cbr\u003e\u003cb\u003ePublisher:\u003c\/b\u003e Springer\u003cbr\u003e\u003cb\u003eLanguage:\u003c\/b\u003e English\u003cbr\u003e\u003cb\u003ePublished:\u003c\/b\u003e 05\/14\/2018\u003cbr\u003e\u003cb\u003ePages:\u003c\/b\u003e 268\u003cbr\u003e\u003cb\u003eFormat:\u003c\/b\u003e Hardcover\u003cbr\u003e\u003cb\u003eWeight:\u003c\/b\u003e 1.30lbs\u003cbr\u003e\u003cb\u003eSize:\u003c\/b\u003e 9.21h x 6.14w x 0.69d","brand":"Andrew Giltrap","offers":[{"title":"Hardcover","offer_id":43941384651007,"sku":"9789811088056","price":139.99,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0662\/2982\/9887\/products\/img_38df16ee-7de2-4b29-bb9e-bd16926a76f9.jpg?v=1681452614","url":"https:\/\/www.whiterainbookhouse.com\/products\/total-synthesis-of-natural-products-andrew-giltrap-9789811088056","provider":"WR Book House","version":"1.0","type":"link"}