{"product_id":"transforming-growth-factor-beta-in-cancer-sonia-b-jakowlew-9781617377365","title":"Transforming Growth Factor-Beta in Cancer Therapy, Volume II: Cancer Treatment and Therapy","description":"Transforming Growth Factor-B in Cancer Therapy, Volume II: Cancer Treatment and Therapy The chapters in this volume confer an abundance of knowledge about the current state ofour understanding oftransforming growth factor-B (TGF-B) in cancer treatment and therapy. Unlike several more traditional positive polypeptide growth factors that stim- ulate cellular proliferation, the prototypical TGF-B is now known to inhibit the growth of most normal cell types, including those of epithelial and mesenchymal origin. However, there are examplesofcell types that can be stimulated by TGF-B under certain conditions. TGF-B also induces the accumulation of matrix molecules by stimulating their synthesis as well as inhibiting their degradation. Moreover, TGF-B induces apoptosis of certain cell types, thereby restricting their proliferation. OveractivityofTGF- has been linked to several diseases. For instance, the effect ofTGF- on matrix accumulation contributes to fibrotic conditions, like glomerulonephritis, lung fibrosis and liver cirrhosis (1). TGF- has a very complicated role in cancer that is only beginning to be understood.\u003cbr\u003e\u003cbr\u003e\u003cb\u003eAuthor:\u003c\/b\u003e Sonia B. Jakowlew\u003cbr\u003e\u003cb\u003eISBN-10:\u003c\/b\u003e 1617377368\u003cbr\u003e\u003cb\u003eISBN-13:\u003c\/b\u003e 9781617377365\u003cbr\u003e\u003cb\u003ePublisher:\u003c\/b\u003e Humana\u003cbr\u003e\u003cb\u003eLanguage:\u003c\/b\u003e English\u003cbr\u003e\u003cb\u003ePublished:\u003c\/b\u003e 11\/19\/2010\u003cbr\u003e\u003cb\u003ePages:\u003c\/b\u003e 786\u003cbr\u003e\u003cb\u003eFormat:\u003c\/b\u003e Paperback\u003cbr\u003e\u003cb\u003eWeight:\u003c\/b\u003e 3.05lbs\u003cbr\u003e\u003cb\u003eSize:\u003c\/b\u003e 10.00h x 7.00w x 1.62d","brand":"Sonia B. Jakowlew","offers":[{"title":"Paperback","offer_id":48485674549503,"sku":"9781617377365","price":279.99,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0662\/2982\/9887\/files\/img_0b4bf5a4-ecaa-4c8c-9616-80bb7b0fb4c3.jpg?v=1778050811","url":"https:\/\/www.whiterainbookhouse.com\/products\/transforming-growth-factor-beta-in-cancer-sonia-b-jakowlew-9781617377365","provider":"WR Book House","version":"1.0","type":"link"}