{"product_id":"transition-metals-in-catalysis-silke-leimkzhler-9783036506081","title":"Transition Metals in Catalysis: The Functional Relationship of Fe-S Clusters and Molybdenum or Tungsten Cofactor-Containing Enzyme Systems","description":"\u003cp\u003eIron-sulfur (FeS) centers are essential protein cofactors in all forms of life. They are involved in many key biological processes. In particular, Fe-S centers not only serve as enzyme cofactors in catalysis and electron transfer, they are also indispensable for the biosynthesis of complex metal-containing cofactors. Among these cofactors are the molybdenum (Moco) and tungsten (Wco) cofactors. Both Moco\/Wco biosynthesis and Fe-S cluster assembly are highly conserved among all kingdoms of life. After formation, Fe-S clusters are transferred to carrier proteins, which insert them into recipient apo-proteins. Moco\/Wco cofactors are composed of a tricyclic pterin compound, with the metal coordinated to its unique dithiolene group. Moco\/Wco biosynthesis starts with an Fe-S cluster-dependent step involving radical\/S-adenosylmethionine (SAM) chemistry. The current lack of knowledge of the connection of the assembly\/biosynthesis of complex metal-containing cofactors is due to the sheer complexity of their synthesis with regard to both the (genetic) regulation and (chemical) metal center assembly. Studies on these metal-cofactors\/cofactor-containing enzymes are important for understanding fundamental cellular processes. They will also provide a comprehensive view of the complex biosynthesis and the catalytic mechanism of metalloenzymes that underlie metal-related human diseases.\u003c\/p\u003e\u003cbr\u003e\u003cbr\u003e\u003cb\u003eAuthor:\u003c\/b\u003e Silke Leimkühler\u003cbr\u003e\u003cb\u003eISBN-10:\u003c\/b\u003e 303650608X\u003cbr\u003e\u003cb\u003eISBN-13:\u003c\/b\u003e 9783036506081\u003cbr\u003e\u003cb\u003ePublisher:\u003c\/b\u003e Mdpi AG\u003cbr\u003e\u003cb\u003eLanguage:\u003c\/b\u003e English\u003cbr\u003e\u003cb\u003ePublished:\u003c\/b\u003e 03\/10\/2021\u003cbr\u003e\u003cb\u003ePages:\u003c\/b\u003e 186\u003cbr\u003e\u003cb\u003eFormat:\u003c\/b\u003e Hardcover\u003cbr\u003e\u003cb\u003eWeight:\u003c\/b\u003e 1.33lbs\u003cbr\u003e\u003cb\u003eSize:\u003c\/b\u003e 9.61h x 6.69w x 0.63d","brand":"Silke Leimkühler","offers":[{"title":"Hardcover","offer_id":48454014370047,"sku":"9783036506081","price":55.4,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0662\/2982\/9887\/files\/img_d740de31-92c2-4581-ae48-2220296fbc6a.jpg?v=1777303650","url":"https:\/\/www.whiterainbookhouse.com\/products\/transition-metals-in-catalysis-silke-leimkzhler-9783036506081","provider":"WR Book House","version":"1.0","type":"link"}