{"product_id":"tumor-suppressor-par-4-vivek-m-rangnekar-9783030735715","title":"Tumor Suppressor Par-4: Structural Features, Molecular Mechanisms and Function","description":"Par-4 is a tumor suppressor protein first discovered and identified in 1993 by Dr. Vivek Rangnekar's laboratory in prostate cancer cells undergoing apoptosis. Par-4 (later also known as PAWR) is a naturally occurring tumor suppressor. Studies have indicated that Par-4 selectively induces apoptosis in cancer cells while leaving normal, healthy, cells unaffected. Mechanisms contributing to the cancer-selective action of Par-4 have been associated with protein kinase A activation of intracellular Par-4 in cancer cells or GRP78 expression primarily on the surface of cancer cells. Par-4 is downregulated, inactivated or mutated in diverse cancers. This first of two volumes will be the first on the market on the topic of Par-4, and will provide the opportunity for researchers to discuss the future direction of studies, broaden the scope of research, and contribute a more complete understanding of the molecule's structural features, key functional domains, regulation and relevant basic and clinical\/translational facets.\u003cp\u003e\u003c\/p\u003e\u003cp\u003e\u003c\/p\u003e\u003cbr\u003e\u003cbr\u003e\u003cb\u003eAuthor:\u003c\/b\u003e Vivek M. Rangnekar\u003cbr\u003e\u003cb\u003eISBN-10:\u003c\/b\u003e 3030735710\u003cbr\u003e\u003cb\u003eISBN-13:\u003c\/b\u003e 9783030735715\u003cbr\u003e\u003cb\u003ePublisher:\u003c\/b\u003e Springer\u003cbr\u003e\u003cb\u003eLanguage:\u003c\/b\u003e English\u003cbr\u003e\u003cb\u003ePublished:\u003c\/b\u003e 01\/09\/2022\u003cbr\u003e\u003cb\u003ePages:\u003c\/b\u003e 323\u003cbr\u003e\u003cb\u003eFormat:\u003c\/b\u003e Hardcover\u003cbr\u003e\u003cb\u003eWeight:\u003c\/b\u003e 1.42lbs\u003cbr\u003e\u003cb\u003eSize:\u003c\/b\u003e 9.21h x 6.14w x 0.75d","brand":"Vivek M. Rangnekar","offers":[{"title":"Hardcover","offer_id":48486762905855,"sku":"9783030735715","price":199.99,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0662\/2982\/9887\/files\/img_e2ac3f9d-5474-43b8-899c-688bdf8d7179.jpg?v=1778056597","url":"https:\/\/www.whiterainbookhouse.com\/products\/tumor-suppressor-par-4-vivek-m-rangnekar-9783030735715","provider":"WR Book House","version":"1.0","type":"link"}