{"product_id":"tuning-autophagy-inducing-activity-and-toxicity-yunjiao-zhang-9789811681684","title":"Tuning Autophagy-Inducing Activity and Toxicity for Lanthanide Nanocrystals","description":"\u003cp\u003eThis thesis presents a simple, yet highly effective surface engineering solution that uses non-covalent binding peptides to control the autophagy-inducing activity of nanomaterials and nanodevices. The author presents RE-1, a short synthetic peptide that sequence-specifically binds to lanthanide (LN) oxide and upconversion nanocrystals with high affinity, which was discovered using an innovative phage display approach. RE-1 effectively inhibits the autophagy-inducing activity and toxicity of these nanocrystals by forming a stable coating layer on the surface of the nanoparticles, and by reducing their sedimentation and cell interaction. RE- 1 and its variants provide a versatile tool for tuning cell interactions in order to achieve the desired level of autophagic response and are useful for the various diagnostic and therapeutic applications of LN-based nanomaterials and nanodevices.\u003cbr\u003e\u003c\/p\u003e\u003cbr\u003e\u003cbr\u003e\u003cb\u003eAuthor:\u003c\/b\u003e Yunjiao Zhang\u003cbr\u003e\u003cb\u003eISBN-10:\u003c\/b\u003e 9811681686\u003cbr\u003e\u003cb\u003eISBN-13:\u003c\/b\u003e 9789811681684\u003cbr\u003e\u003cb\u003ePublisher:\u003c\/b\u003e Springer\u003cbr\u003e\u003cb\u003eLanguage:\u003c\/b\u003e English\u003cbr\u003e\u003cb\u003ePublished:\u003c\/b\u003e 01\/10\/2023\u003cbr\u003e\u003cb\u003ePages:\u003c\/b\u003e 156\u003cbr\u003e\u003cb\u003eFormat:\u003c\/b\u003e Paperback\u003cbr\u003e\u003cb\u003eWeight:\u003c\/b\u003e 0.56lbs\u003cbr\u003e\u003cb\u003eSize:\u003c\/b\u003e 9.21h x 6.14w x 0.37d","brand":"Yunjiao Zhang","offers":[{"title":"Paperback","offer_id":44130445885695,"sku":"9789811681684","price":179.99,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0662\/2982\/9887\/files\/img_5d366913-e087-42ef-9ad0-31397d41e046.jpg?v=1687469409","url":"https:\/\/www.whiterainbookhouse.com\/products\/tuning-autophagy-inducing-activity-and-toxicity-yunjiao-zhang-9789811681684","provider":"WR Book House","version":"1.0","type":"link"}