{"product_id":"voltage-gated-calcium-channels-gerald-werner-zamponi-9783031088803","title":"Voltage-Gated Calcium Channels","description":"This book covers the tremendous progress in the current understanding of the molecular physiology of voltage-gated calcium channels. This book includes unparalleled insights into structural features of calcium channels due to X-ray crystallography and cryo-EM, which in turn yielded critical information into how these channels function under normal and pathophysiological conditions, and how they interact with calcium channel therapeutics. The chapters investigate how, with the advent of high throughput genome sequencing, numerous mutations in various calcium channel genes have been identified in patients with neurological, cardiovascular, neuropsychiatric and other disorders. This is further complemented through a much larger in vivo toolkit such as knock-out and knock-in mice. The chapters further discuss the increased complexity of calcium channel physiology that arises from mRNA editing and splicing. Finally, the book also provides an overview of the updated research on calcium channel inhibitors that can be used both in vivo and in vitro, and which may serve as a spring board for new calcium channel therapeutics for human disease. Voltage-Gated Calcium Channels is useful for academic researchers at all levels in neuroscience, biophysics, cell biology and drug discovery.\u003cbr\u003e\u003cbr\u003e\u003cb\u003eAuthor:\u003c\/b\u003e Gerald Werner Zamponi\u003cbr\u003e\u003cb\u003eISBN-10:\u003c\/b\u003e 3031088808\u003cbr\u003e\u003cb\u003eISBN-13:\u003c\/b\u003e 9783031088803\u003cbr\u003e\u003cb\u003ePublisher:\u003c\/b\u003e Springer\u003cbr\u003e\u003cb\u003eLanguage:\u003c\/b\u003e English\u003cbr\u003e\u003cb\u003ePublished:\u003c\/b\u003e 11\/09\/2022\u003cbr\u003e\u003cb\u003ePages:\u003c\/b\u003e 710\u003cbr\u003e\u003cb\u003eFormat:\u003c\/b\u003e Hardcover\u003cbr\u003e\u003cb\u003eWeight:\u003c\/b\u003e 3.21lbs\u003cbr\u003e\u003cb\u003eSize:\u003c\/b\u003e 10.00h x 7.00w x 1.50d","brand":"Gerald Werner Zamponi","offers":[{"title":"Hardcover","offer_id":44364943065343,"sku":"9783031088803","price":219.99,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0662\/2982\/9887\/files\/img_f96236e7-5943-4f7e-8869-a74574abcfef.jpg?v=1697055745","url":"https:\/\/www.whiterainbookhouse.com\/products\/voltage-gated-calcium-channels-gerald-werner-zamponi-9783031088803","provider":"WR Book House","version":"1.0","type":"link"}