Autism Spectrum Disorder (ASD) presents a complex puzzle. While recent genetic advances have identified genes linked to ASD, the vast variation in symptoms (phenotypic heterogeneity) among individuals remains a mystery. This is particularly puzzling in simplex autism, where only one child in a family...

Our bodies need protection against pathogen invasion and for that we employ our immune system which is armed with an arsenal of cells and proteins. This immune network is destined to eliminate microbes and substances determined to pose significant threat to the normal functioning...

In the high-pressure world of critical care, every second counts. But what if there was a way to anticipate a patient's decline before a crisis strikes? "Critical Care: Predicting Before Crisis" explores the revolutionary world of early warning systems, designed to give medical professionals...

Depression isn't just a personal struggle; it's a global challenge impacting an estimated 280 million people. This mental health condition significantly disrupts daily life, affecting work, relationships, and physical health. The causes are multifaceted, ranging from social and economic stressors to biological factors. The...

Despite progress, esophageal cancer survival rates vary significantly. Early detection plays a crucial role. Unfortunately, symptoms like heartburn can be mistaken for less serious issues, leading to later diagnosis when the cancer is more aggressive. Additionally, socioeconomic factors can impact access to quality healthcare...

The ICU isn't just about saving lives; it's about sustaining families. Witnessing a loved one in critical condition can be overwhelming. ICU staff recognizes this, extending their support beyond the bedside. Social workers become anchors, navigating the complexities of healthcare decisions and discharge planning....

Anesthesia keeps us comfortable during surgery, but what happens at the cellular level? " Halothane & Muscle Dysfunction " delves into the fascinating science behind how certain anesthetics, like halothane, impact our cellular machinery. This book explores how halothane disrupts the delicate process of...

AR in Surgery: Planning the Future The operating room has long been a realm of meticulous precision and unwavering focus. But the future of surgery is being reshaped by a groundbreaking technology - Augmented Reality (AR). AR overlays digital information onto the real world,...

The lifeline of our spinal cord is a complex network of arteries and veins. The main players are the vertebral arteries, supplying blood from the brain. They branch off to form the anterior and posterior spinal arteries, running along the front and back of...

Heart attacks, a leading cause of death globally, may hold less fear in the future thanks to advancements in technology. Researchers are exploring exciting possibilities for repairing and regenerating damaged heart muscle after an attack. One approach utilizes messenger RNA (mRNA) technology, similar to...

The delicate pink periwinkle flower, a symbol of resilience, holds a surprising warrior within. Vinca alkaloids, natural compounds found in periwinkle (Catharanthus roseus), have become a powerful weapon in the fight against cancer. These alkaloids, particularly vinblastine and vincristine, disrupt cell division, a crucial...

As lifespans increase, so too does the prevalence of age-related neurodegenerative diseases like Alzheimer's and Parkinson's. These conditions, characterized by the progressive decline of brain function, pose a significant threat to individual and societal well-being. The aging brain undergoes a complex dance of cellular...

Laser surgery is a viable method for excising small to moderate-sized laryngeal cancers, providing an alternative to radiotherapy or traditional surgery. The ideal candidates for laser procedures typically present with small vocal cord malignancies, although medium-sized vocal cord tumors and those affecting other laryngeal...

Emerging challenges related to socio-demographics and economics require new approaches for academics, politicians, hospital management, clinical staff, public institutions, and firms doing business in the healthcare industries. This book provides valuable insights for understanding modern and complex healthcare market configurations in Europe. Taking a...

Mental health disorders such as depression, anxiety, and other stress-related disorders are highly prevalent and even increasing in incidence globally, while access to evidence-based therapy remains limited. Worryingly, health care budgets are further restrained, thus limiting the availability of mental health care even more....

In recent years, increasing attention has been paid to water quality and environmental aspects related to sediment transport, driven by both ambient forcing and human activities. Estuarine, coastal, and harbor areas often undergo operations to nourish beaches, to maintain navigation channels, and to remove...

The incidence of gluten-related disorders (GRDs) continues to increase and its global prevalence is estimated affect to 5% of the population. s. Celiac disease (CD), Dermatitis Herpetiformis (DH), Gluten Ataxia (GA), wheat allergy (WA), and Non-Celiac Gluten Sensitivity (NCGS) are the five major GRDs...

There has been much speculation about a possible antibiotic Armageddon; this would be the result of having untreatable post-operative infections, and similarly untreatable complications after chemotherapy. The now famous "O'Neill Report" (https: //amr-review.org/) suggests that more people could die from resistant bacterial infections by...

The search for bioactive marine natural products calls for the need of efficient chemical profiling strategies, together with the need to make advances in separation and characterization methodologies, in order to expedite their discovery. This Special Issue of Marine Drugs aims to highlight advances...

This special issue brings together cutting edge research and insightful commentary on the currentl state of the Cancer Nanomedicine field.Author: Clare HoskinsISBN-10: 3039431048ISBN-13: 9783039431045Publisher: Mdpi AGLanguage: EnglishPublished: 09/15/2020Pages: 424Format: HardcoverWeight: 2.45lbsSize: 9.61h x 6.69w x 1.31d

Rheumatoid Arthritis (RA) is a chronic inflammatory disease leading to joint inflammation and destruction. Treatment of RA includes the use of conventional (cs), biologic (b) disease-modifying anti-rheumatic drugs (DMARDs), and oral or intraarticular (IA) glucocorticoids (GCs). All different classes of drugs have shown to...

Most complex respiratory conditions invoke interactions between genetic and environmental factors, such as smoking, pollution, and diet. There is increasing evidence that diet and nutrition are important factors, not only in disease prevention, but also in their contribution to the chronicity and heterogeneity of...

This book entitled Marine Algal Antioxidants, as a special issue of the Antioxidants journal, encloses eleven scientific articles with a preface written by the two editors, Christophe Brunet and Clementina Sansone. Marine Algal Antioxidants book reports advances of the research on marine photosynthetic organisms...

The relationship of oral disease to overall disease is certainly not a new concept. For centuries, the role of oral infection and inflammation in contributing to diseases elsewhere in the body has been studied and reported. During the last few decades, a series of...

This book is a collection of chapters around the theme of parasitology and zoonosis in bot war and peace and the impact of these fields on public health. Individual experts have contributed reviews, novel research, and case series within the field to make a...

Rare kidney diseases comprise a large group of different life-threatening or chronically debilitating disorders that affect very small numbers of people (Author: Gianluigi ZazaISBN-10: 303936782XISBN-13: 9783039367825Publisher: Mdpi AGLanguage: EnglishPublished: 08/21/2020Pages: 168Format: HardcoverWeight: 1.25lbsSize: 9.61h x 6.69w x 0.63d

Nutraceuticals are a challenge for the future of prevention and therapy in healthcare. The possibility to prevent and/or support pharmacological therapy, which is nowadays mainly based on pharmaceuticals, can be a powerful tool to face pathological, chronic, long-term diseases in subjects who do not...

This book provides an overview of the design and physico-chemical properties of nanoparticles developed for biomedical applications such as targeting and detection of pathologies, nanovectorization of drugs, radiosensitization, metal detection, and nanocomposite implants. The considerations necessary when developing a new nanomedicine are also developed,...

Cancer remains one of the main causes of morbidity and mortality worldwide. Although many pharmacological and clinical advances have been made, there is a constant need for new molecules to improve the overall options for treatment. Natural compounds from animal, microbial, vegetal, or fungal...

Advanced Blood-Brain Barrier Drug Delivery is a reprint with a summary editorial, followed by 16 chapters that cover five areas of brain drug delivery, including receptor-mediated transport (RMT), carrier-mediated transport (CMT), active efflux transport (AET), Trojan horse lipid nanoparticles (LNP), and in vivo methods...

This book contains research articles on the advances in the aetiology of idiopathic scoliosis (IS), the spinal growth related to the implementation of growth modulation for the surgical treatment of early-onset IS, the non-surgical treatment of IS using Physiotheraputic Scoliosis Specific Exercises, and braces....

The word "cancer" is associated with at least 100 different pathologies, depending on the organ involved and the type of tumor developed. Cancer is a complex disease involving multiple pathogenetic mechanisms. Characterization of different types of cancers, which distinguishes them from healthy cells and...

Interest has grown regarding natural plant extracts in food and beverage applications, their vital role in the food industry, and their therapeutic use against diseases. The protective effects of healthy diets are partially due to the variety of plant metabolites, particularly phenolic compounds, which...

The search for dietary patterns or food bioactive derivatives that may serve as a panacea for health issues has been a topic of interest for several millennia. It is not surprising that this trend in food research is continuing today particularly in relation to...

Mitochondria, organelles surrounded by a double membrane and with their own small genome, are the cells' energy centers. Besides the production of ATP through cellular respiration, mitochondria play a pivotal role in other aspects of the life and death of a cell: heat production,...

The book collects scientific contributions aiming at describing the common mechanism, across living species, by which innate immunity interacts with nanomaterials with the goal of harnessing such interactions for improving environmental and human safety and exploiting them for modulating immunity in vaccination strategies.Author: Diana...

This e-book summarises the latest advances in the rheumatic diseases with a focus on the recent efforts of vascular and pulmonary manifestations and anticipate the new and future directions of these research topic. Rheumatic diseases represent a heterogeneous group of severe autoimmune disorders. The...

On March 11, 2020, the World Health Organization declared COVID-19 a global pandemic and the disease now affects nearly every country and region. Caused by SARS-CoV-2, COVID-19 presents significant challenges to health systems and public health in both hemispheres as well as to the...

In 1900, Paul Ehrlich, who was studying ricin and abrin at the time, discovered antibodies and paved the way for immunotherapy. After 120 years, Ehrlich's insight into the therapeutic potential of immunotargeting is still a source of inspiration for many scientists. One of the...

The first all-Russia conference with international participation "Basic Research in Endocrinology: A Modern Strategy for the Development and Technologies of Personalized Medicine" was held in Novosibirsk on 26-27 November 2020. The purpose of this conference was to disseminate the latest basic and clinical findings...

Immunotherapy in multiple myeloma, first investigated with allogeneic stem cell transplantation, is now a major pillar in the treatment of multiple myeloma. CAR-T-cell technology, monoclonal or bispecific antibodies, as well as new forms of cellular therapy, have revolutionized the treatment of this hematological malignancy.Author:...

This compendium describes the impact of COVID-19 pandemic on all aspects of people lives. Data presented in this collection will be useful to understand the disruption in healthcare, learning, and socio-economic aspects amidst the pandemic. The sooner we begin to understand the impact, the...

The practice of regular physical activity has been proposed as a determinant in many disciplines, from wellness to physiotherapy; in fact, it reduces the risks of cardiovascular diseases and diabetes. Moreover, physical exercise decreases the incidence of some types of cancer, such as breast...

Dear Colleagues, There is increasing interest regarding the protective effect of dietary patterns on a series of metabolic diseases as compared to specific food items and nutrients, since it is well accepted that foods act synergistically. In recent years, the Mediterranean diet (MD) has...

This Special Issue covers both the in vitro and in vivo evaluation of marine carotenoids with anti-inflammatory and anticancer activities as well as clinical trials conducted in humans. Among the properties of carotenoids discussed in this book, it is worth highlighting the potential of...

This book represents a collection of paper from different specialists involved in the management of septic patients, aimed to disseminate the knowledge in the field of sepsis, particularly to non-intensivists physicians.Author: Antonio MirijelloISBN-10: 3036524835ISBN-13: 9783036524832Publisher: Mdpi AGLanguage: EnglishPublished: 12/27/2021Pages: 146Format: HardcoverWeight: 1.14lbsSize: 9.61h x...

Cardiovascular disease (CVD) currently represents one of the leading causes of death worldwide. Each year, more than 17.9 million people die due to CVD manifestations. To reverse these manifestations, the transplantation of secondary vessels or the use of synthetic vascular grafts represents the gold...

Medicinal plants have been used for the maintenance of human health since ancient times, in the form of food, spices, and traditional medicines. Medicinal plant-based traditional medicines serve as the primary healthcare systems in various countries even in recent times. Alongside this, medicinal plants...

Asthma is a multifaceted and puzzling disease. In the present book, well-known scholars offer their expert opinions and revise aspects of our current knowledge of this disease. Using new data (available in the upcoming Global Asthma Network study) on the epidemiology of asthma to...

It is estimated that about 15% of all animals spread across the majority of lineages are venomous. Animals use venom for various purposes including prey capture, predator deterrence, sexual combat and the provision of food for their offspring. Humans have always been fascinated by...