A Comprehensive Guide to Rodent Models of Liver Diseases (Paperback) (ISBN-13: 9780323994781)

A Comprehensive Guide to Rodent Models of Liver Diseases provides the why, what, and how of preclinical models of liver disease. These models have not only substantially improved understanding of human liver disease pathogenesis, but have also helped in developing and testing newer therapeutics and addressing some of the unanswered medical challenges and problems of today. This important reference gives a detailed and in-depth review of the various animal models of human liver disease. Well-reported animal models of several human liver diseases such as fatty liver disease (non-alcoholic and alcoholic) to steatohepatitis, cholestasis, fibrosis, cirrhosis and end-stage primary liver cancer are described. Preclinical models used for studying liver regeneration and liver failure are also discussed. For each model, the characteristic features, updated protocols, relevance, and limitations are provided for consideration. Finally, it provides an overview of the recently developed organoid models of liver pathology.