A Guide to Sample Size for Animal-Based Studies (Paperback) (ISBN-13: 9781119799979)

Understand a foundational area of experimental design with this innovative reference

Animal-based research is an essential part of basic and preclinical research, but poses a unique set of experimental design challenges. The most important of these are the 3Rs - Replacement, Reduction and Refinement - the principles comprising the ethical framework for humane animal-based studies. However, many researchers have difficulty navigating the design trade-offs necessary to simultaneously minimize animal use, and produce scientific information that is both rigorous and reliable.

A Guide to Sample Size for Animal-based Studies meets this need with a thorough, accessible reference work to the subject. This book provides a straightforward systematic approach to "rightsizing" animal-based experiments, with sample size estimates based on the fundamentals of statistical thinking: structured research questions, variation control and appropriate design of experiments. The result is a much-needed guide to planning animal-based experiments to ensure scientifically valid and reliable results.

This book offers:

• Step-by-step guidance in diverse methods for approximating and refining sample size
• Detailed treatment of research topics specific to animal-based research, including pilot, feasibility and proof-of-concept studies
• Sample size approximation methods for different types of data - binary, continuous, ordinal, time to event - and different study types - description, comparison, nested designs, reference interval construction and dose-response studies
• Numerous worked examples, using real data from published papers, together with SAS and R code

A Guide to Sample Size for Animal-based Studies is a must-have reference for preclinical and veterinary researchers, as well as ethical oversight committees and policymakers.

Author: Penny S. Reynolds
ISBN-10: 111979997X
ISBN-13: 9781119799979
Publisher: Wiley-Blackwell
Language: English
Published: 09/12/2023
Pages: 288
Format: Paperback
Weight: 1.49lbs
Size: 11.00h x 8.50w x 0.61d