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Twenty-first century neuroscience has discovered that in some severe cases, addiction may so constrain human freedom that the will is only able to choose to use substances of abuse. At this advanced stage, substance use has become the primary driver of salience, co-opting
and subsuming other moral priorities and human rewards. Scholars have investigated Aristotle's concept of akrasia as an ancient mirror of this understanding and there have been some preliminary discussions of Augustine's concept of the divided will as it bears on addiction.
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