Alzheimer's Disease: Methods and Protocols (Paperback) (ISBN-13: 9781617371615)

Alzheimer's disease is the most common cause of senile dementia. Since the discovery in 1984 of the amyloid ?-peptide (A?) as the core protein of the senile plaques present in the brains of Alzheimer's disease sufferers, an immense amount of research has gone into mapping out the molecular basis of this debilitating disease. The aim of Alzheimer's Disease: Methods and Protocols is to bring together the main biochemical, cell biological, and molecular biological techniques and approaches that are being used to investigate the molecular basis of Alzheimer's disease. This volume begins with chapters of an introductory/ review nature. Chapter 1 provides a historical introduction to Alzheimer's d- ease with particular emphasis on the central role played by A? and its re- tion to tau. Chapter 2 examines the genetics underlying this neurodegenerative disease, covering the amyloid precursor protein, apolipoprotein E, and the presenilins. Chapter 3 presents an overview of currently available therapeutic agents and prospects for drugs of the future.

Author: Nigel M. Hooper
ISBN-10: 1617371610
ISBN-13: 9781617371615
Publisher: Humana
Language: English
Published: 11/09/2010
Pages: 408
Format: Paperback
Weight: 1.36lbs
Size: 9.00h x 6.00w x 0.94d